Term
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Definition
Systemic Circuit: Carries blood through the body
Pulmonary Circuit: moves blood through gas exchange surfaces of the lungs |
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Term
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Definition
| simultaneous depolarization of right and left atria |
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Term
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Definition
| ventricular depolarization |
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Term
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Definition
| ventricular repolarization |
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Term
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Definition
Digitalis purpurea (common floxglove)
Rx of CHF
Digoxin: narrow therapeutic index |
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Term
| Digitalis Signs and Symptoms |
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Definition
Non Sepcific
acute OD: children (hyper kalemia)
chronic OD: elderly
CNS: delerium fatigue
"whitish-yellowish halo vision"
CV: tachycardia, preventricular beats, bradyrythmias |
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Term
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Definition
conditions indicate tox better than bound drug levels
Kayexelate(Napolystyrnen sulfonate-hyper kalemia
lidocaine- AV arrhythmia
beta blocker- ventricular arrhythmia |
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Term
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Definition
digoxin-specific antibody
derived from immunized sheep
competitively binds and removes circulating receptor bound digoxin |
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Term
| Beta- Adrenergic Antagonists |
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Definition
used in treatment of hypertension, angine, arrythmias, CHF, ischemic heart dieases
open angle glaucoma
migraine headaches(off label use) |
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Term
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Definition
CV: brady cardia, hypotension, "quinidine like blockade"
CNS: sedation, psychosis, siezures
Pulmonary: bronchospastic disease |
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Term
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Definition
supportive (improve CV contracitility, increase HR, restore perfusion *admin dopamine*)
atropine (antimuscarcinic with sympathetic effects will counteract beta)
beta agonist (isoproretenol)
Glucagon (increase ionotropy/chronotropy) |
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Term
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Definition
| Found in heart, coronary vessels, liver |
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Term
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Definition
| found in lungs, muscle, and sympathetic target organs |
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Term
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Definition
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Term
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Definition
drugs diminish contractile force without affecting Action Potential
-induce excitation-contraction uncoupling
MORE CALCIUM IN HEART
VASODILATION |
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Term
| Toxicity of Ca2+ channel blockers |
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Definition
excessive vasodilation (dizziness, hypotention, HA, flushing nausea)
constipation, peripheral edema,pulmonary edema
SEVERE INTOX: negative ionotropic, depresses cardiac contraction, shock & hypotension |
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Term
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Definition
supportive
glucagon
atropine
catecholamines (cariotonic drugs) |
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Term
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Definition
angiotensin converting enzymes, block this decreasing formation of angiotensin II (vasopressor involved in maintaining systemic BP)
used to treat hypertesntion , CHF, renal disease
Catopril, enalapril |
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Term
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Definition
| manage angin pectoris, CHF, PVD |
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Term
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Definition
Direct Vasodilator
MOA: increases GMP
Tox:
1. hypotension, HA, nausea..
2. autoimmune reactions: lupus serum sickness, hemolytic anemia (result of T-cell autoreactivity) |
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Term
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Definition
Direct Vasodilator
MOA: increases GMP--> produces vasodilation
MOT:
excessive vasodilation and hypotension
conversion to cyanide and thiocyanate
anion gap metabolic acidosis (increased risk of CV terminal events) |
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Term
| Class 1A Arrhythmia drugs |
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Definition
quinidine: depress mycocardial Na & K channels
Tox: cv compromise, CNS (lethargy,coma
cinchonism & diarrhea |
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Term
| Class 1B Arrhythmia drugs |
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Definition
lidocaine: depress mycocardial Na & K channels
TOX: CNS (coma, siexure,nystagmus) |
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Term
| Class IC AntiArrythmic drugs |
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Definition
| Flecanide (incrase sodium channels?) |
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Term
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Definition
Amiodarone:
MOT: pulmonary fibrosis, heart failure?) |
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