Term
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Definition
thiazide
I: HTN, CHF, hypercalciruria
MOA: inhibits Na/Cl cotransporter of distal convoluted tubule so decreased Na+ reabsorption
SE: hypokalemia
sulfa allergy |
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Term
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Definition
MOA: inhibits cotransport of Na/K/2Cl in ascending loop of Henle
I: edema, CHF, hypercalcemia, hyperkalemia esp in renal insufficient pts
SEL ototoxic, hyperuricemia, hypokalemia, hypomagnesemia, hypocalcemia |
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Term
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Definition
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Term
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Definition
loop diuretic
MORE ototoxic |
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Term
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Definition
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Term
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Definition
k+ sparing
MOA: block Na/K antiport in collecting tubule
SE: hyperkalemia, leg cramps, hyperuricemia |
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Term
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Definition
K+ sparing
MOA: steroid that antagnoizes aldosterone receptor
I: secondary hyperaldosteronism, diuretic, CHF
SE: gynecomastia, menstural irregularities |
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Term
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Definition
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Term
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Definition
acetazolamide
furosemide
torasemide
hydrochlorothiazide
NOT ethacrynic acid and K+ sparing |
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Term
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Definition
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Term
hydralazine
-MOA
-I
-SE
-give with? |
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Definition
arterial vasodilator
MOA: activation of K channels->hyperpolarization of SM membrane->inhibited Ca influx->SM relaxation
I: HTN and pregnancy HTN
SE: reflex tachycardia, increased CO, Lupis like syndrome
give w/ a B-blocker and diuretic |
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Term
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Definition
organic nitrate-vasodilator of EVERYTHING
I: HTN emergency
SE: cyanide poisoning |
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Term
| What 9 categories of drugs are used for HTN? |
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Definition
1. diuretic
2. vasodilators
3. adrenergic receptor blockade (B blockers)
4. neuronal blockade
5. NT depletion
6. CNS
7. Ca Channel Blockers
8. ACE inhibitors
9. ARBs |
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Term
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Definition
Non-selective B blocker; reduce CO and PVR
I: antiangina, HTN, arrythmias, migraines prophylaxis, CHF, glaucoma, MI
CI: Asthma (use metoprolol instead) and may worsen CHF
SE: mask a hypoglycemic event in diabetic |
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Term
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Definition
MOA: a1 selective adrenergic antagonist->decreases PVR
I: HTN and Raynaud's disease
SE: dizziness, tachycardia, palpitations, orthostatic hypotension |
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Term
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Definition
MOA: B1 selective blocker; reduce CO and PVR
I: same as propranolol and better for asthmatics |
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Term
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Definition
Non-selective B-blocker
I: HTN w/ bradycardia |
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Term
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Definition
Non-selective B-blocker
I: HTN AND glaucoma
MOA: decreases production of aqueous humor by ciliary body, decrease IOP |
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Term
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Definition
Neuronal blockade
MOA: blocks the release of stored NE (opposite of tyramine); depletion of NE and reduced PVR and CO |
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Term
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Definition
NT depletion
MOA: blocks Mg/ATP transport of NE into vesicles
SE: severe mental depression |
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Term
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Definition
a2 agonist
I: HTN, drug withdrawal
MOA: binds to a2 in CNS, decreasing sympathetic outflow
SE: sedation, dry mouth, rebound hypertension |
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Term
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Definition
a2 agonist that decreases sympathetic outflow in CNS
I: HTN and HTN pregnancy
SE: sedation |
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Term
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Definition
MOA: dihydropyridine Ca channel blocker; relaxes vascular SM esp veins and coronary aa
SE: reflex tachycardia |
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Term
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Definition
ACE inhibitor
I: HTN, CHF, post-MI, diabetic renal protective
SE: Sulfa drug, hyperkalemia, angioedema, persistent dry cough
CI: pregnancy |
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Term
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Definition
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Term
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Definition
| ACE inhibitor active form |
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Term
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Definition
ARB
MOA: competitive antagonist of the angiotensin type 1 receptor
I: same as ACE plus good for cough
CI: pregnancy |
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