Term
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Definition
| Method of genetic analysis in which a phenotype is first related to a DNA variation, then the protein involved is identified |
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Term
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Definition
| (1) In gene cloning, a gene of identifiable phenotype that indicates the presence of another gene, DNA segment, or chromosome fragment. (2) In general, a DNA sequence such as a single nucleotide polymorphism whose presence is correlated with the presence of other linked genes on that chromosome. |
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Term
| Restriction fragment length polymorphism |
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Definition
| the coexistence of two or more patterns of restriction fragments resulting from underlying differences in DNA sequence. |
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Term
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Definition
| A mutation that results from the gain, loss, or substitution of a single nucleotide. |
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Term
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Definition
| A mutation resulting from the loss of a continuous segment of a gene or chromosome. Such mutations almost never revert to wild type. |
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Term
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Definition
| A condition in which one or more chromosomes or pieces of chromosomes are either lacking or present in excess. |
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Term
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Definition
| (1) In genetics, a rare mutational event that moves a portion of a chromosome to a new location, generally on a nonhomologous chromosome. (2) In vascular plants, movement of solutes in the phloem. |
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Term
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Definition
| A three-base-pair sequence in a human gene that is unstable and can be repeated a few to hundreds of times. Often, the more the repeats, the less the activity of the gene involved. Expanding triplet repeats occur in some human diseases such as Huntington’s disease and fragile-X syndrome. |
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