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CSIM 4
Neoplasia 1
10
Medical
Undergraduate 2
03/25/2013

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Term
What is cell atrophy?
Definition
A decrease in cell size.
Term
What is cell hypertrophy?
Definition
Increase in the size of cells.
Term
What is hyperplasia?
Definition
An increased number of cells.
Term
What is metaplasia?
Definition
A reversible change of one adult cell type to another. It represents the adaptation of a sensitive cell type to a more resistant cell type in an adverse environment.
Term
What is dysplasia?
Definition
Deranged differentiation.
Term
Describe epithelial dysplasia.
Definition
1) Loss of orientation. Disordered maturation
2) Atypical morphology: altered nuclear size, pleomorphism, hyperchromasia, increased nuclear/ cytoplasmic ratio
3) Increased mitotic activity, often suprabasal.
Term
What is carcinoma in situ?
Definition
Severe epithelial dysplasia but no invasion through the basement membrane.
Term
Which form of cell adaptation is always pathological?
Definition
Dysplasia.
Term
Define neoplasm.
Definition
An abnormal, unco-ordinated proliferation of tissue that persists after stimulus cessation.
Term
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Definition
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