Term
| What is the most common cause of primary hyperuricemia? |
|
Definition
| uric acid undersecretion (80-90%) |
|
|
Term
| What group is gout more common in? |
|
Definition
|
|
Term
| Where is uric acid filtered and where does 80% get reabsorbed? |
|
Definition
| filtered in the glomerulus and 80% is reabsorbed in the proximal tubules |
|
|
Term
| What is the classic clinical example of acute gouty arthritis? |
|
Definition
| acute pain and swelling in 1 joint |
|
|
Term
| what develops as a result of recurrent attacks of gout? |
|
Definition
| tophi and chronic tophaceous gout |
|
|
Term
| How is the diagnosis of gout confirmed? |
|
Definition
| exam of synovial fluid with urate crystals-needle shaped |
|
|
Term
| What is a drug of choice for initial treatment of acute gout and can be helpful in establishing the diagnosis? |
|
Definition
|
|
Term
| What is the most widely used NSAID for gout? |
|
Definition
|
|
Term
| What dietary item should be monitored closely with gout? |
|
Definition
| alcohol consumption, especially beer |
|
|
Term
| What is the most commonly used uricosuric drug for chronic hyperuricemia? |
|
Definition
|
|
Term
| What is the MOA of allopurinol? |
|
Definition
| inhibits xanthine oxidase which stops production of purines |
|
|
Term
| What joints are most commonly involved with osteoarthritis and CPPD? |
|
Definition
|
|
Term
| What is the birefringenece result and crystal apperance in CPPD? |
|
Definition
| weakly positive birefringence and rhomboid or rod shaped |
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