Term
| What is elimination half-time vs elimination half-life? |
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Definition
| Half time describes the amount of time it takes to reduce the serum concentration by half, while half life describes the amount of time it takes to reduce the amount in the entire body |
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Term
| Name 3 drugs eliminated via zero order kinetics |
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Definition
| Phenytoin, alcohol, and ASA |
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Term
| Do infants have a relatively larger or smaller Vd? |
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Definition
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Term
| Do infants require more or less sux/kg than adults? What about NDMBA's? |
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Definition
| Require more sux due to increased Vd and immature neuromuscular junction. NDMBA's are about the same; there is more required due to larger Vd, but the junction is immature so it balances out |
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Term
| What drug undergoes first-order, one compartment kinetics? |
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Definition
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Term
| What is the formula for determining volume of distribution (Vd)? |
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Definition
| Vd= Q/Cp(t=0) where Q is the injected quantity and Cp(t=0) is the concentration once the initial distribution phase is over |
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Term
| Which drugs are considered weak acids? |
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Definition
| Barbiturates (pentothal) and propofol |
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Term
| When looking at drug names, what ion substrates indicate the compound is a weak acid? |
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Definition
| anything with positively charged ions, such as Na, Mg, or Ca (ex. sodium pentothal) |
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Term
| When looking at compound names, which ionic substrates indicate the drug is a weak base? |
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Definition
| Anion substrates, such as Cl or SO4 (ex morphine sulphate) |
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Term
| What local anesthetic can cause methemoglobinuria? |
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Definition
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Term
| Which form of local (ionized vs. non) for conduction block to occurr? |
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Definition
| Both (Ionized form to bind to the voltage-gated Na channel inside the cell and unionized to get into the cell) |
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