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Contraindications in Pregnancy
drugs in pregnancy
23
Medical
Graduate
04/29/2010

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Cards

Term
Contraindicated Antibiotics
Definition
Fluroquinolones (C)- arthropathy
Trimethoprim/sulfamethoxazole (C)- nerual tube defects, kernicterus
Tetracycline (D)- grey teeth
Aminoglycosides (D) - ototoxicity
Term
Approved Antibiotics
Definition
Penicillin (B)
Maybe: Cephalosporins, Monobactams (B)
Term
Contraindicated Anticoagulation Therapy
Definition
Warfarin (X)- "warfarin syndrome"
ASA (C)- Low dose safe in 2-3rd trimester, in 1st trimester risk of gastroschisis
Term
Approved Anticoagulation Therapy
Definition
Heparin Low Molecular Weight (B)
Heparin Unfractionated (C)
Term
Uncontrolled asthma in pregnancy causes
Definition
IUGR, Preeclampsia
Term
Approved Asthma therapy
Definition
1st: Inhaled Budesonide (B)
2nd: Albuterol (C)
3rd: Salmeterol (C)
Term
Uncontrolled Depression in pregnancy
Definition
Delivering low birth weight infant
Preterm delivery
Small-for-gestational age infant
Term
Contindicated Antidepressants
Definition
Paroxetine (D)- Cardiac birth defects, skull closes too fast, anencepthaly, gastoschisis
Term
Approved Antidepressants
Definition
SSRIs (C)- not Paroxetine
SNIRs (C) > 28 weeks
Term
Affects of TCAs after birth
Definition
Withdrawal: Jerky movements, tachypnea, tachycardia, feeding difficulty, diffuse sweating, irritability
Term
Contraindicated Diabetes Control
Definition
Oral Agents: Metformin, Glipizide, Glyburide, Sulfonylureas
Term
Approved Diabetes Control
Definition
Regular Human insulin (B)
Term
Risks of uncontrolled gestational diabetes
Definition
Macrosomia
Cesarean delivery
Shoulder dystocia, birth trauma
Neonatal metabolic problems (Hypoglycemia, hypocalcemia, hyperbilirubinemia, polycythemia)
Perinatal mortality
Term
Contraindicated Dyslipidemia Therapy
Definition
Statins (X)- spontaneous abortion, neonatal death, structural defects, IUGR, limb dysplasia, CNS midline defects
Term
Approved Dyslipidemia Therapy
Definition
TRY NOT TO TREAT
LDL:Bile Acid sequestrants(B)-Colesevlam
TG: Omega 3 fatty acids (C)- Lovaza
Term
Complications of Chronic HTN in Pregnancy
Definition
Premature birth
IUGR
Fetal demise
Placental abruption
Cesarean delivery
Term
Contraindicated Antihypertensives
Definition
Beta-blockers ATENOLOL!!(D)
Thiazide diuretics (B)
ACE inhibitors (C,then D)
ARBs (C, then D)
Term
Approved Antihypertensives
Definition
1st: Methyldopa(B) - alpha-2 agonist
2nd: Labetalol (C) - alpha/beta blocker
3rd: Hydralazine (C)
Term
FDA Class A
Definition
Controlled studies show no risk to fetus
Studies in pregnant women show no risk in any trimester
Term
FDA class B
Definition
No evidence of risk in humans
Studies in pregnant women have shown no risk despite animal adverse findings OR Animal studies show no risk in absence of human studies
Term
FDA class C
Definition
Risk cannot be ruled out
Human studies lacking; fetal risk in animals; use if benefits > risks
Term
FDA Class D
Definition
Positive evidence of risk
Human studies have shown fetal risk Only use if benefits DEFINITELY > risks
Term
FDA Class X
Definition
CONTRAINDICATED IN PREGNANCY
Human or animal studies have shown fetal risk that outweighs any possible benefit to patient
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