Term
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Definition
| reactive hyperplasias, neoplasms , fibrohistocytic |
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Term
|
Definition
peripheral fibroma
general gingival hyperplasia
focal fibrous hyperplasia
denture induced fibrous hyperplasia |
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Term
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Definition
overexuberant repair follows injury
color = light pink to red
no nerve tissue prof. = no pain
treatment- surgical excision / removal of irritating factor |
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Term
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Definition
a reactive hyperplastic mass that occurs on gingiva ( derived from submucosa / PDL connect)
predilect- young adults
gender - more females
raised nodule pedunculated or sessile
color - matches tissue
ulceration may occur , rarely causes erosion of bone |
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Term
| focal fibrous hyperplasia |
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Definition
aka hyperplastic scar , highly collagenous ( overprod) and avascular , may contain chronic infiltrate
gingival counterpart to traumatic fibroma
very comon in buccal mucosa, lat border of tongue and lower lippainless , broad based swelling
dont exceed 1-2 cm in diameter |
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Term
| peripheral fibroma subtypes |
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Definition
peripheral ossifying
giant cell
peripheral odontogenic
retrocuspid papilla |
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Term
| peripheral fibroma - differential diagnosis |
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Definition
pyogenic granuloma -red
peripheral giant cell gran. - blue
exision with pdl |
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Term
|
Definition
may be autosomal dominant - cowdens syndrome
oral fibromas, cutaneous papula, neoplasms of breast ,thyroid and colonic polyps
PTTEN ( tumor suppressor ) |
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Term
| generalized gingival hyperplasia causes and modifiers |
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Definition
local factors - plaque , calculus, bacteria
hormonal imbalance - estrogen, testerone
drug - phenytoin( dilantin) , cyclosporine, nifedipine and Ca blockers
leukemia
genetic factors |
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Term
| generalized gingival hyperplasia |
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Definition
abundance of collagen and fibroblasts are increased in number , chronic inflammation
have a hereditary basis
( treatment - gingivoplasty /attentive oral hygiene |
|
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Term
| denture induced fibrous hyperplasia |
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Definition
epuliss fissuratum
prolonged removal of denture |
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Term
|
Definition
benign proliferation of spindle cells of probable fibroblastic origin
oral lesions- buccal mucosa
age-adults |
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Term
| histo path of solitary fibrous tumor |
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Definition
lesions are circumscribed , patternless prolif. of spindle cells
leiomyoma, hemangiopericytoma, benighn fibrous histiocytoma
immuno- positive for CD34
most cases benign, beavior unpredictabble
10-15% behave aggressively - long term followup ( poor correlation btw histo and overall behavior |
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Term
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Definition
benign soft tissue neoplasma composed of gelatinous material myxoid app.
site- palate
-no predilec
oral soft tissue myxoma is rare - slow growing , asymptomatic submucosal mass
excludes autosomal dominant. |
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Term
| soft tissue myxoma - histopath |
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Definition
not encapsulated and may exhibit infiltration, loose myxoid stroma
diffuse and blending |
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Term
| treatment of soft tissue myxoma |
|
Definition
surgical excision , recurrenoce is not uncommon
all are benign processes, and require conservative therapy only |
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Term
| nasopharyngeal angiofibroma ( juv. nasopharyngeal angiofibroma) |
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Definition
uncommon to rare benign, 20s , always affects boys, nasopharynx,
rarely lesions may present intraorally causing palatal expansion - appear blue
symptom triad - recurrent epistaxis, nasal obstruction, mass effect within nasopharynx |
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Term
| histopath of nasopharyngeal angiofibroma |
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Definition
well collagenated lesion
cleft like vascular channels
uniform , benign app. |
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Term
| treatment - JNPA ( juv. nasophary angfibroma |
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Definition
may exhibit agg. clinical behav. in which direct ext. into bones of midface and skull base
recurrence up to 50% due to incomp. excision , invasive nature of lesion and surfgical diff. anatom loc. |
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Term
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Definition
rare benign soft tissue -first described in the orbit ( submand, orbit, extraorbital and oral cavity
- patternless round to spindle
positive to vimentin and CD34
multinucleated floret type giant cell with nuclei at periphery of cell
local excision |
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Term
| nodular fasciitis ( pseudosarcomatous fasciitis ) |
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Definition
rapid growth clinically that malignancy suspect
young adults and adults
sites- trunk and extremities
no predilection
intraorally buccal mucosa |
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Term
| histopath of nodular fasciitis |
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Definition
nodular growth pattern,
storiform arrangement
myxoid areas are often found
multinucleated giant cell and normal mitotic figure
inflamm cells and extravasated RBCs |
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Term
| differential diagnosis of nodular fasciitis |
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Definition
fibromatosis
fibrous histiocytoma
fibrosarcoma
myofibroma |
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Term
| IHC of nodular fasciitis express |
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Definition
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Term
| treatment of nodular fasciitis |
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Definition
| conservative surgical incision |
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Term
|
Definition
myofibromatosis - multifocal -occur infants
prolif of myofibroblast
myofibroma- solitary -over a wide age range, predilection for head and neck
circumscribed mass |
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Term
| myofibroblastic histopath |
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Definition
tumor show pushing , well demarcated borders
paucicellular lobules with hyalinized or collagenous stroma alternate with cellular zones
uniform with tapered nuclei
biphasic growth pattern, with fascicles of myoid appear spindled cells surrounding nodules of rounded pericyte like cells |
|
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Term
|
Definition
+ for smooth muscle actin
(-) for desmin
(-) CD 34
(-) S-100 |
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Term
|
Definition
myofibromas arae begning and local excision is curatie
multiple lesions dont represent recurrence but multifocal disease , if deep and involves visceral lesion and mortality rate approaching 80% |
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