Shared Flashcard Set

Details

Conditions and Syndromes
Ready for action notes with imaginative situations
10
Medical
Post-Graduate
12/08/2013

Additional Medical Flashcards

 


 

Cards

Term
Cryopyrin-associated periodic syndromes (CAPS)
Definition
syn. to autoinflammatory syndromes
Term
Familial cold autoinflammatory syndrome (FCAS)
Definition
one of autoinflammatory syndromes AD PFS + rash and conjunctivitis precipitated by exposure to cold
Term
Muckle-Wells syndrome (MWS)
Definition
one of autoinflammatory syndromes
AD
CAIS1 defect
Sensorineural deafness and urticaria
Term
Autoinflammatory syndromes, types
Definition
FMF
Hyperimmunoglobulinemia D with recurrent fever (HIDS)
CAPS
Periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA syndrome)
Blau syndrome
Pyogenic sterile arthritis, pyoderma gangrenosum, acne (PAPA)
Deficiency of the interleukin-1–receptor antagonist (DIRA)
Term
Autoinflammatory syndromes, pathogenesis
Definition
NLRP3 mutations (encoding cryopyrin)
unregulated production of IL-1 beta
Clinically: Periodic fever syndrome
complications: AA amyloidosis
Rx:
Canakinumab: ab specific for IL-1 beta
Rilonacept: a fusion protein composed of IL-1 receptor and Fc portion of IgG1
Anakinra: IL-1 receptor antagonist
Term
Hyperimmunoglobulin D with recurrent fever (HIDS)
Definition
Periodic fever syndrome +
mouth ulcer and diarrhea
inc. IgD and often IgA
Mevalonate kinase defect, a part of the HMG-CoA reductase pathway (cholesterol synthetic pathway)
Rx: as usual
Statins may help
Term
Hand and Foot conditions
Definition
Acromegaly: hand and foot edema Dengue fever: hand and foot edema and flushing Hand and Foot syndrome: Chemotherapy-induced acral erythema Hand, foot and mouth disease
Term
Hand, foot and mouth disease
Definition
Picornaviridae
febrile illness followed by a maculopapular rash of hands, feet and mouth
Term
Foot and mouth disease
Definition
Picornaviridae
affect sheep, cows
not transmitted to humans
Term
Hand and foot syndrome
Definition
Chemotherapy-induced acral erythema:
Capecitabine
Supporting users have an ad free experience!