Term
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Definition
| Classical pathway: binds to pathogen-bound antibody; provides site for C1r and C1s association. |
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Term
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Definition
| Classical pathway: Along with C1s, binds to C1q; activates C1s, creating the C1 complex |
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Term
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Definition
| Classical pathway: along with C1r, binds to C1q; once activated by C1r, becomes cleaving component of the C1 complex |
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Term
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Definition
| Classical pathway: the antibody bound C1q-C1r-C1s complex that cleaves C4 and C2 |
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Term
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Definition
| Classical & MBL: Cleaved by C1 complex into C4a and C4b. C4b binds with C2a to form C3 convertase |
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Term
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Definition
| Classical & MBL: cleaved by C1 complex into C2a and C2b; C2a binds with C4b, forming C3 convertase |
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Term
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Definition
| All: cleaves C3 into C3a and C3b |
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Term
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Definition
| peptide mediator of inflammation |
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Term
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Definition
| an opsonin; the main effector molecules of the complement system. Binds with C3 convertase to form C5 convertase. |
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Term
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Definition
| C3 convertase-C3b complex; cleaves C5 into C5a and C5b |
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Term
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Definition
| most important and potent inflammatory peptide |
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Term
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Definition
| initiates the late events of complement activation; with C6, C7, C8, and C9, forms membrane attack complex. |
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Term
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Definition
| MBL: Mannose binding lectin; binds to pathogen surfaces, providing site for MASP-2 and MASP-1 association. |
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Term
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Definition
| MBL: "Mannose-Binding Protein-Associated Serine Proteases;" along with MBL, form complex capable of cleaving C4 and C2 (alternative pathway equivalent of C1 complex) |
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Term
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Definition
| Alternative: binds with C3b (from hydrolyzed C3) to be cleaved by Factor D |
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Term
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Definition
| Alternative: Cleaves B once B is bound to C3b |
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Term
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Definition
| MBL: portion of cleaved B that binds with C3b, forming C3bBb, a C3 convertase |
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Term
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Definition
| MBL: stabilizes pathogen surface bound C3bBb (C3 convertase) complex |
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Term
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Definition
| Along with C5b, form membrane attack complex; a part of later events of complement activation |
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