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colon disorders
colon disorders
129
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07/06/2011

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Term
Constipation
Definition
defined as having a bowel movement less than 3 times a week.


Constipation is a SYMPTOM, not a DISEASE!!!
Term
Clinical definition of constipation is having any two of the 2 symptoms for at least 12 weeks, not always executive, in the past year:
Definition
Straining
Hard, lumpy stool
Sensation of incomplete evacuation
Sensation of blockage or obstruction
Fewer than 3 BMs each week.
Term
One of the most common GI complaints
Definition
Constipation
Term
Constipation- Causes
Definition
Decreased fiber intake
Elderly
ignoring the urge to have a BM
Dehydration
Inactivity
IBS
Pregnancy
Abuse of laxatives
Medications
Diseae (stroke, parkinsons, hypothyroidism, lupus, hyperparathryoidism, uremia, spinal cord injuries)
Term
Diseases that cause constipation
Definition
Stroke, Parkinson’s, DM, hypothyroidism, lupus, hyperparathryoidism, uremia, spinal cord injuries
Term
Constipation- Tests
Definition
Colorectal transit study
Anorectal manometry
Balloon expulsion Test
Defecography
Barium enema
Colonoscopy/sigmoidoscopy
Term
Constipation- Treatment
Definition
Increase Fiber
Increase activity
Bulk-forming laxatives- generally the safest. Watch for medicine interference. Ex. Metamucil, citrucel. Watch for bloating and abd pain.
Stimulants – ex Correctol, Senokot, Dulcolax
Osmoitics- watch for electrolytes in pts with DM.
Term
Saline laxatives
Definition
draw water into colon. Watch for electrolyte imbalance in children and pts with renal disease.
Term
Anal Fissure
Definition
small or tear in the anal mucosa that may cause painful bowel movements and bleeding.
Term
Extremely common in young infants
Definition
Anal Fissure
Term
Anal fissures- Symptoms
Definition
Pain while having bowel movement
Blood on the surface of the stool and NOT mixed in with the stool.
Blood on toilet paper
A crack in the skin (usually in the midline) that is visible when the anus is stretch.
Constipation, usually with painful bowel movements.
Term
Anal Fissures-Causes
Definition
Constipation and/or straining with bowel movements.
Inflammation of the anorectal area (i.e. IBD)
Prolonged diarrhea
In older individuals, decreased blood flow
Women after childbirth
Anal sex (rarely)
Term
Anal Fissure- Risk factors
Definition
Infancy-80% will have one before age 1 (cause unknown)
Advanced age- circulatory problem with low flow to the rectum
Constipation- with straining increases risk of tearing.
Childbirth
IBD such as Crohn’s (chronic inflammation)
Term
Anal Fissure-Diagnosis and complications
Definition
Diagnosis-
DRE
Visual examination of rectal mucosa

Complications-
Most (90%) heal on their own. However, some become chronic and may require minor surgery to relax the sphincter.
Term
Anal Fissures- Treatment
Definition
Most heal on their own without medical treatment. Most symptoms go away within 2 weeks; however, it may take up to 6-8 weeks for the fissure to heal.
Term
Anal Fissures- Non surgical options
Definition
Nitrogylcerin ointment to anus
Botox to the internal sphincter (can last up to 3 months)

Rectal corticosteroids such as Anusol or Preparation H
Add fiber to your diet (20-35gms)
Increase fluids
Exercise
Sitz bath
Avoid constipation/straining
Term
Fecal Incontinence
Definition
Fecal incontinence is the inability to control one’s bowels.
Unable to hold your bowel movements until you get to a toilet or
Stool leaks from rectum
Term
Fecal Incontinence -Causes
Definition
Constipation
Damage to anal sphincter muscles
Weakness of muscles (i.e. during childbirth and episiotomy or hemorrhoid surgery)
Nerve damage
--Unable to sense stool in rectum (i.e. childbirth, stroke, DM, MS)
Loss of storage capacity in rectum (decrease elasticity from radiation, IBS)
Rectal cancer
Diarrhea
Pelvic floor dysfunction
Term
Pelvic floor dysfunction
Definition
Decreased ability to sense stool
Increased muscle contractions
Rectal prolapse
Rectocele- protusion of the rectum through the vagina
General weakness of the muscles
Childbirth is often the culprit however, it does not show up until the 40+
Term
Fecal Incontinence- Risk factors
Definition
Female gender > male gender
Nerve damage (i.e DM, MS)
Alzheimer’s disease –often a late sign and is usually a combination of both nerve damage and memory problems.
Physical disability
Term
Fecal incontinence- Diagnosis
Definition
Visual examination- hemorrhoids, infections
Check nerve damage with pin or probe
DRE
Term
measures the function of the anal sphincter and the function of the rectum
Definition
Anal manometry
Term
evaluates structures of the rectum and sphincter.
Definition
Anorectal ultrasound-
Term
the barium helps to visualize the walls of the rectum and to measure the amount of stool your rectum can accommodate and how it is evacuated from the rectum.
Definition
Proctography
Term
- visualize last 2 feet of colon for inflammation and tumors
Definition
Proctosigmoidoscopy
Term
looks for signs of nerve damage.
Definition
Anal electromyography
Term
Fecal incontinence- Treatment
Definition
Changes in diet i.e. constipation or diarrhea causing the problem.
Medications
Stool softeners
Laxatives
Anti-diarrheal
Bowel training
Term
which helps to repair damaged muscles surrounding the anal sphincter
Definition
Sphincteroplasty
Term
abscess in the natal cleft
99% are actually abscesses NOT cysts
Definition
Pilonidal Cyst
Term
Pilonidal Cyst –Risk Factors
Definition
Male sex
Obesity
Inactive lifestyle
Excessive body hair
Poor hygiene
Increased sweating
Term
Pilonidal Cyst- Treatment
Definition
Incision and drainage

Surgery
Watch out for bleeding and infection after surgery!!
Term
Pilonidal Cyst- Prevention
Definition
Basic hygiene
Remove hair i.e shaving, depilatories, or laser hair removal.
Clean and wash area daily.
Keep area clean and dry
Term
an inflammation of the rectum
Definition
Proctitis
Term
Proctitis causes
Definition
STDs –Most common
Inflammatory Bowel Disease i.e. Crohn’s, UC
Non-sexually transmitted infections (strep, Salmonella, shigella, Campylobacter)
Radiation
Antibiotic Use
Chemicals/Medication i.e enemas
Trauma
Term
most common cause of proctitis
Definition
STDs –Most common
Term
Proctitis - Symptoms
Definition
Bloody stools
Rectal discharge
Rectal pain
Tenesmus
Term
Proctitis –Risk Factors
Definition
Anal sex
IBS
Using antibiotics
Radiation therapy (i.e. prostate cancer)
Term
Proctitis - Diagnosis
Definition
Rectal Culture
Colonoscopy/sigmoidoscopy
Stool culture
Blood test/culture
STD screening
Term
Infectious Proctitis
Definition
Treat STDs with abx
For proctitis associated with abx use- Flagyl or vanc
Term
Radiation Proctitis
Definition
Iron
Ablation therapy
Term
IBS
Definition
Corticosteroids and/or anti-inflammatories (Sulfasalazine or mesalamine)
Surgery
Term
Proctitis complications
Definition
Anemia
Fistulas (i.e. recto-vaginal fistula, anal fistula)
Term
Hemorrhoids
Definition
Hemorrhoids are enlarged, painful veins in the rectum.
Internal hemorrhoids- cluster of tissue within the anal canal and are located above the pectinate line.
External hemorrhoids are enlarged blood vessels around the anus.
Term
Hemorrhoids - Symptoms
Definition
BRBPR
Painful bowel movement
Constipation
Itching
Painful, swollen area around the anus.
Term
Hemorrhoids - Causes
Definition
Constipation
Diarrhea
Inactivity
Obesity
Pregnancy (increased weight/pressure and hormonal changes.
Term
Hemorrhoids - Diagnosis
Definition
DRE
Internal hemorrhoids may not be felt.


Flexible sigmoidoscopy or colonoscopy
Term
Hemorrhoids-Treatment
Definition
Usually try non-surgical options
Stool softeners
Hemorrhoidal creams/suppositories (Anusol, preparation H)
Increasing water and fiber consumption
Warm soaks/sitz bath
Astringents (burning, itching, pain)
Calamine, zinc oxide, witch hazel
Term
Treatment for internal hemorrhoids
Definition
Rubber band ligation

Sclerotherapy

Infrared Coagulation
Hemorrhoidectomy
Term
Rubber band ligation
Definition
Complications include bleeding, cellulitis/abscess, sepsis
Treatment for internal hemorrhoids
Term
Phenol or quinine urea injected at base of hemorrhoid—causes inflammation then scarring
Definition
Sclerotherapy
Term
1-2 second burst of light cut off circulation to small internal hemorrhoids.
Definition
Infrared Coagulation
Term
Hemorrhoids- Complications
Definition
Internal hemorrhoids –bleeding, prolapse, incarceration, and gangrene. PAIN IS NOT COMMON!

External hemorrhoids- bleeding and PAIN!
Term
External hemorrhoids
Definition
bleeding and PAIN!
Term
Internal hemorrhoids –
Definition
bleeding, prolapse, incarceration, and gangrene. PAIN IS NOT COMMON!
Term
Rectal prolapse
Definition
rectal tissue protrudes through the anal canal.
May see a red colored mass protruding from the anus.
Caused by weak ligaments and muscles that hold rectum in place.
Term
Mucosal prolapse
Definition
when only the rectal mucosa is expelled from anus and not the entire wall.
Term
Internal intussusception
Definition
when the rectum collapses but does NOT expel from the anus.
Term
Rectal Prolapse - Symptoms
Definition
Painful bowel movements.
BRBPR
Fecal incontinence
Awareness of tissue protruding
Loss of urge to have a bowel movement.

Often similar to hemorrhoids but rectal prolapse originates higher in the rectum than hemorrhoids.
Term
Rectal Prolapse -Causes
Definition
Pinworms
Cystic fibrosis
Malnutrition (ex. Celiac disease)
Long-term constipation/diarrhea/straining
Injury to anus
Pregnancy
MS
COPD
Term
child under 6 with rectal prolapse: rule out
Definition
cystic fibrosis
Term
helps to differentiate between mucosal prolapse and complete prolapse.
Definition
Defecogram
Term
Rectal Prolapse - Treatment
Definition
Fiber as bulking agent
Stool softeners
Surgery
Term
surgery for rectal prolapse
Definition
Abdominal approach usually used in younger patients has higher morbidity rate with 3-7 day hospital stay
Perineal approach usually on older patients because no anesthesia is needed with lower morbidity rate; however, it has a higher recurrence rate.
Term
Appendicitis- Symptoms
Definition
Early pain is often generalized (periumbilical). Once the irritation enlarges and the peritoneum around the appendix becomes inflamed, then the pain is localized to the RLQ.
Term
early appendicitis
Definition
periumbilical
Term
appendicitis Often hard to diagnose in the following population of people:
Definition
Pregnant females
Children
Elderly
Immunosuppressed
DM
Obese
Term
an outpouching of the small intestines usually located in the RLQ.
Definition
Meckel’s diverticulitis
Term
pelvic exam in females for
Definition
appendicitis
Term
Appendicitis- DDX
Definition
PID
Right-sided diverticulitis
Kidney disease – (ex. Stones, abscess)
Crohn’s
Right ovarian cyst
Ectopic pregnancy
diverticulitis
Term
Appendicitis- Tests
Definition
CBC
BMP
UPT
UA
CT scan of the abd/pelvis WITH CONTRAST!
Term
Tests the iliopsoas muscle group (hip flexers)
Definition
Psoas Sign

Test by passively extending the thigh of the patient with knees flexed.
Position patient of left side and passively extend right leg behind patient
Or, with patient supine- flex hips to 90 degrees and ask patient to flex knee against resistance
Term
Patient is supine with right leg flex at 90 degrees. The provider holds the patients right ankle in his right hand. With the left hand, the provider rotates the right hip by pulling the right knee to and away from the patient's body.
Definition
Obturator Sign
Term
Appendicitis- Treatment
Definition
Surgery (appendectomy)
Open vs Lap
Once perforation AND abscess formation- Abx therapy and CT guided drainage tube places with surgery several weeks/months later.
The risk of perforation after 36 hours of symptoms is at least 15%!!
Term
Peritonitis
Definition
Peritonitis is inflammation of the peritoneum which is the membrane that lines the abdominal cavity and organs
Can be localized or generalized
Can be infectious or non-infectious
Usually is a surgical emergency!!!
Term
Usually is a surgical emergency!!!
Definition
Peritonitis
Term
Peritonitis- Symptoms
Definition
Abdominal pain
Abdominal distension
Washboard abdomen often with generalized
Fever
Nausea/vomiting
Decreased urine output
Constipation
Tachycardia
Cloudy dialysis fluid
Term
Peritonitis- Causes
Definition
Peritoneal dialysis
Cirrhosis causes ascites
Perforation (appy, stomach, colon)
Leakage of sterile body fluids (gastric juice, bile, urine)
Pancreatitis
Diverticulitis
Crohn’s
Penetrating trauma
Term
Peritonitis –Risk Factors
Definition
History of peritonitis
Cirrhosis
Appendicitis
Diverticulitis
Pancreatitis
Ulcers
ESRD on peritoneal dialysis
Term
Peritonitis- Diagnosis
Definition
Peritoneal fluid counts and culture
CBC
CMP (liver profile ? Cirrhosis)
Xrays to look for free air
CT scan
In trauma –exploratory peritoneal lavage
Term
Peritonitis - Treatment
Definition
Antibiotics
Broad spectrum (remember fungal)
Most are Staph aureus and coagulase-neg staph
Surgery to remove the infection
Except SBP
Supportive measures
IVF
Electrolytes
Term
Peritonitis - Complications
Definition
sepsis

With early and appropriate treatment, mortality rate is <10%
However, this number increases to 40% in people with numerous medical problems, the elderly, and individuals who present late!!!!
Term
Intestinal Obstruction -Signs
Definition
Cramping abdominal pain
Nausea/vomiting
No bowel movements or passing gas
Abdominal distension
Abdominal tenderness
Term
Intestinal Obstruction -Causes
Definition
Small intestines causes include: adhesions, hernia, and tumors (less likely intussusception, volvulus, or stricture)
Obstruction of the large intestines is less common (10-15%) where adhesions and hernias RARELY cause the obstruction.
Causes are cancer, diverticulitis, volvulus
Less common is intussusception, stricture, FB, impaction of feces.
Term
Intestinal Obstruction –Risk factors
Definition
Crohn’s –chronic inflammation causing narrowing of lumen
Cancer
Constipation
Malrotation of intestines (congenital)
Term
stairstepping on XR
Definition
obstruction
Term
Intestinal obstruction- treatment
Definition
Supportive care (electrolytes, IVF)
NG tube for decompression
Watchful waiting
Surgery
Term
Adynamic ileus
Definition
Is when the bowel does NOT function properly but there in NOT a mechanical issue.

Very common in infant, children, and post-op
Term
Adynamic Ileus- Causes
Definition
Metabolic( especially K)
Medications
Mesenteric ischemia
Intra-abdominal surgery
Injury to blood supply
Term
Adynamic Ileus- findings
Definition
Abd distension
Abd pain
Cramping
N/V
Constipation/diarrhea
Bad breath
Term
Adynamic Ileus- Test
Definition
Abd xrays
CT scan with contrast
Barium enema
Upper GI series with SBFT
Term
Adynamic Ileus Vs Mechanical Obstruction
Definition
LISTEN WITH STETHOSCOPE!!!


Adynamic ileus will have quiet or absent bowel sounds.

Mechanical obstruction will have high pitched sounds!!
Term
auscultations for adynamic ileus
Definition
quiet/absent bowel sounds
Term
auscultations for mechanical obstruction
Definition
high pitched sounds
Term
Adynamic Ileus -Treatment
Definition
NG Tube to suction
Correct electrolytes
Limit narcotics!!
Watchful waiting
Surgery (watch for necrotic tissue)
Term
Adynamic Ileus- Complications
Definition
Infection
Gangrene
Perforation/Peritonitis
Term
Colitis
Definition
Non-specific term for a variety of conditions
Diarrhea, abdominal pain, bowel spasms, tenesmus
Mild or severe, benign or serious
Systemic illness and/or localized
Includes Inflammatory Bowel Disease
Term
Causes of Colitis
Definition
IBS
Ischemic
Hemolytic-Uremic Syndrome (E. coli)
Collagen Vascular dz, Autoimmune dz
Radiation, Medication
Metastatic or Vascular disease
Lymphoma
Infectious
Term
Ischemic Colitis
Definition
Common bowel complaint of elderly
Acute or Chronic
Crampy left abd pain partly relieved by defecation
Usually BRBPR or hematochezia
Usually with other manifestations vascular disease
Term
Ischemic Colitis
Definition
Gut blood flow
Celiac artery supplies stomach, pancreas, hepatic arteries
Ischemia rare here
Superior mesenteric supplies most of small bowel and ascending and transverse colon
Inferior mesenteric supplies distal transverse to rectum
Extensive collateralization
Term
Acute Ischemic Colitis
Definition
Sudden onset but may have prodrome of chronic ischemia
SMA embolus 50%
Non-occlusive ischemia 30%
SMA thrombus 25%
Venous thrombus 5%
Term
Acute Ischemic Colitis symptoms/signs
Definition
Rapid onset severe pain
Pain precedes vomiting
Initial exam non-specific
Peritoneal signs as infarction occurs
Non-specific lab studies
Mesenteric angiography gold standard
Term
Acute Ischemic Colitis treatment
Definition
Treat supportively
Surgical consult
Angioplasty or thrombolysis
Treat or manage embolic source
Hypercoagulation work-up
Term
Persistent Severe Colitis May Be Inflammatory Bowel Disease (IBD)
Definition
Crohn’s Disease or Ulcerative Colitis
Pathogenesis poorly understood
Crohn’s Disease - transmural mucosal inflammation
Ulcerative colitis – inflammation limited to mucosa and submucosa
Term
Crampy left abd pain partly relieved by defecation
Definition
Ischemic Colitis
Term
Pain precedes vomiting
Definition
Acute Ischemic Colitis
Term
Second cause of death from cancer in US!!
Definition
Colon Polyps
Term
Abnormal cell growth in colon.
Definition
Colon Polyps
Term
Colon Polyps- Signs
Definition
Rectal Bleeding
BRBPR
Melena
Pain
Constipation
Obstruction
Term
can be either small or large but ARE FLAT!!!
Definition
sessile polyps
Term
are attached to a stalk and mushroom shaped.
Definition
Pedunculated colon polyps
Term
less likely cancerous than large, sessile polyps
Definition
Small polyps and pedunculated polyps
Term
3 types of colon polyps
Definition
Adenomatous
Hyperplastic
Inflammatory
Term
Adenomatous colon polyps
Definition
Increased risk of malignancy if >5mm or greater (1/4 inch)
Malignancy increases even more if >10mm
Account for 75% of all polyps
Term
Hyperplastic colon polyps
Definition
Usually on the Left side/ rectum
Usually <5mm
Rarely malignant
Term
Colon Polyps risk factors
Definition
Overweight
Smoker
Family history
High fat, low fiber diet
Over age 50
Genetic mutation
Adenamatous polyposis coli (APC)
Term
Colon Polyps -Tests
Definition
DRE
Hemocult
Colonoscopy/ Sigmoidoscopy
Barium Enema
Genetic Test
Pillcam –small bowel
Term
Familial Adenomatous Polyposis(FAP)
Definition
Defect of APC gene
Rare
People develop thousands of polyps throughout the colon.
Start in the teenage years
Risk of colon cancer is 100% if left untreated.
Term
Risk of colon cancer is 100% if left untreated.
Definition
Familial Adenomatous Polyposis(FAP)
Term
Gardner’s Syndrome
Definition
Variant of FAP
Mutation of APC
Develop thousands of polyps throughout colon AND small intestines
Also have tumors develop throughout body.
Skin (lipomas, cysts)
Bone (osteomas)
Abdomen (desmoids)
Term
Turcot’s Syndrome
Definition
Rare (100 cases)
Mutation of APC (location 5q21)
Autosomal dominant or recessive
Characterized by colon polyps AND tumors of the central nervous system
Gliomas
Medulloblastoma
People with TS are at a 92% increased risk to develop CNS tumors.
Term
Characterized by colon polyps AND tumors of the central nervous system
Definition
Turcot’s Syndrome
Term
Develop thousands of polyps throughout colon AND small intestines
Definition
Gardner’s Syndrome
Term
Peutz-Jeghers Syndrome
Definition
Mutation of the STK11 gene.
Autosomal dominant
Characterized by hamartomatous polyps in GI tract
Average age of diagnosis is age 23
Half of population die by age 57 and risk of cancer between ages of 15-64 is 93%
Most patients die from complications associated with obstruction or cancers of pancreas, liver, lungs, breast, ovaries, testicles
Term
Characterized by hamartomatous polyps in GI tract

Mutation of the STK11 gene.
Definition
Peutz-Jeghers Syndrome
Term
3 Main criteria for diagnosis
Peutz-Jeghers Syndrome
Definition
Family history
Mucocutaneous lesions of hyperpigmentation on mouth, hands and feet (usually on gingivia, hard palate, and cheek.
Hamartomatous polyps in GI tract (benign)
Having 2 out of the three is a positive diagnosis
Term
Juvenile Polyposis
Definition
Mutation of the BMPR1A (20%) and SMAD4 gene
Autosomal Dominant
Development of polyps in stomach, small intestines, colon, rectum.
The term juvenile refers to type of polyp NOT the age of onset, although most people do develop polyps by age 20.
Risk of cancer varies from 9-50% (stomach, Upper GI tract, and pancreas.
Term
Cronkite-Candida Syndrome
Definition
Not hereditary
Rare
Idiopathic (unknown cause)
Age range of 50-65
Two-thirds are Japanese with male to female ratio of 2:1
Term
Associated with chronic diarrhea and protein loss.

May have alopecia, atrophy of nails, skip pigmentation of skin
Definition
Cronkite-Candida Syndrome
Term
Neurofibromatosis
Definition
Autosomal Dominant
Neural crest origin and therefore can affect any organ system.
Several subtypes but GI involvement is associated with NF1
Associated with neurofibromas in liver and GI tract.
Associated with SB leiomyomas, GIB, obstruction and large bowel intussusception. a
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