Term
Not effective orally or IV
Topical use to cause Miosis
Short acting 10 minutes
N and M agonist
Very sensitive to Ach |
|
Definition
|
|
Term
Stimulate ganglia, adrenal medulla, and skeletal muscle
SE: tremors, convulsions, respiratory paralysis, CTZ stimulant(nausea) |
|
Definition
|
|
Term
| Tests responsiveness of airway in asthmatics (M3R) |
|
Definition
| metacholine (provocholine) |
|
|
Term
N and M effects
resistant to ACHE
Stimulate GI/Bladder (often after surgery)
Glaucoma
Miosis |
|
Definition
|
|
Term
Selective M
resistant to ACHE
GI/Bladder stimulant
Urinary stimulant
SE: sweating, salivation, bronchospasm, accommodation problems |
|
Definition
|
|
Term
Natural alkaloid, M actions
Stimulates sweat, salivary, and gastric glands
Uses:glaucoma, GI, Xerostomia, looked at in AD.
Crosses BBB |
|
Definition
|
|
Term
Natural alkaloid (betelnut)
N and M activity
Looked at in AD
No activity of ACHE |
|
Definition
|
|
Term
M activity
No activity of ACHE
from mushroom |
|
Definition
|
|
Term
M3 agonist on salivary/lacrimal glands
Oral, long acting stimulation of salivation |
|
Definition
|
|
Term
natural alkaloid in Calaber bean
orally active, but only available as injection
Crosses BBB
Uses: mitotic in glaucoma, atropine toxicity
SE: M effects |
|
Definition
|
|
Term
Doesn't enter CNS
oral and injection
Uses: paralytic ileus, urinary retention, MG (short t1/2 multiple doses), reverse NM blockade |
|
Definition
|
|
Term
orally available
longer duration than neostigmine
uses: MG
narrow therapeutic index |
|
Definition
|
|
Term
CNS selective
Uses: AD (doesn't stop prorgression)
QID
Hepatotoxicity limits use |
|
Definition
|
|
Term
Similar to neostigmine
slower onset, longer duration, oral, injection
Uses: MG, Prophylactic to nerve gas, reverse NM blockade |
|
Definition
|
|
Term
Injection
Very short duration of action(10 minutes) b/c blocks anionic site (lacks carbamoyl grp)
Diagnosis of MG |
|
Definition
|
|
Term
Used for AD
Daily dosing, no liver disease
Effective in up to 80%
may slightly slow progression
M side effects |
|
Definition
|
|
Term
AD
BID dosing
SE: liver, GI, bronchoconstriction, drowsiness
About as effective as donepezil |
|
Definition
|
|
Term
AD, BID
Selective for G1 isoform found mainly in brain.
SE: muscarinic (less b/c selective), hallucinations |
|
Definition
|
|
Term
Treatment for organophosphate exposure (2 drugs)
1)blocks M actions of too much Ach
2) reacts w/ OP and pulls of enzyme |
|
Definition
| 1)Atropine, 2)Pralidoxime(2-PAM) |
|
|
Term
Belladonna alkaloid
Non-selective M blockade
Uses: mydriasis, bradychardia (due to inc. PS), GI hyperactivity, bronchodilation |
|
Definition
|
|
Term
| Antidote for atropine overdose |
|
Definition
|
|
Term
prophylaxis of motion sickness,
mydriasis, amnesia, CNS depression, "Twilight sleep" |
|
Definition
|
|
Term
Bladder selective
for Overactive Bladder
Adverse effects: dry mouth, constipation, blurred vision, QT prolongation
CI: glaucoma, gastroparesis, GI obstruction, urinary retention |
|
Definition
| Tolterodine, fesoterodine(prodrug) |
|
|
Term
For urinary incontinence
SE: dry mouth, dry eyes
transdermal and gel formulations for less SEs |
|
Definition
|
|
Term
| As effective as oxybutynin but less SEs. 60% excreted by kidneys unchanged (can use in pts with liver problems, adjust does in impaired renal function) |
|
Definition
|
|
Term
Selective M3 antagonist-slightly more selective for bladder, less dry mouth and eye
CYP3A4 ints |
|
Definition
|
|
Term
tremor in Parkinsons
Balance DA release(doesn't stop progression)
CNS excitation
(L-dopa only effective for ~10 yrs, so could use these first to treat tremor then L-dopa movement problems arise) |
|
Definition
| benztropin, trihexyphenidyl |
|
|
Term
M1 selective
decrease acid secretion in GI |
|
Definition
|
|
Term
hypertensive crisis
controlled hypotension in surgery
hyperreflexia in spinal injuries
tourette's syndrome
cocaine, nicotine withdrawal |
|
Definition
|
|
Term
depolarizing blocker, agonist
rapidly metabolized by esterases
fast onset, short duration |
|
Definition
|
|
Term
| MOA: briefly activates N receptor (muscle fasciculations, bradycardia,then tachycardia). Desensitizes motor endplate |
|
Definition
|
|
Term
Uses: surgery, intubations, fractures
electroshock
convulsive disorders |
|
Definition
|
|
Term
Side effects: Histamine release on rapid infusion (hypotension, bronchspasm)
K+ release (avoid with tissue damage..burns)
Malignant hyperthermia
Infants less sensitive |
|
Definition
|
|
Term
Non-depolarizing antagonist
Doesn't cross GI or BBB
No anesthetic properties
4-6 min onset, 80-120 min duration |
|
Definition
|
|
Term
Side Effects:
Newborns extremely sensitive
Histamine release
Interacts with anesthetic gases
Antidote:physostigmine |
|
Definition
|
|
Term
5-10x more potent than curare
no histamine release
medium ganglionic blocking effects |
|
Definition
|
|
