Term
| Five Major Components of ECM |
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Definition
Collagen - must abundant Elastin - stretching Proteoglycans - ECM Adhesive Glycoproteins - binding cells to other components of the ECM (fibronectin and laminin)
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Term
| Five Major Types of Collagen |
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Definition
Collagen I (Fibrillar) - tendon, skin, ligament Collagen II (Fibrillar) - cartilage Collagen III (Fibrillar) - skin vessels, gendon Collagen VI (Fibrillar) - cartilage associ w/type I Collagen IV (Filamentous) - vessels, skin |
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Term
| 4 Connective Tissue Components |
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Definition
- Collagen
- Elastin
- Proteoglycan
- Adhesive Glycoproteins
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Term
| 5 MAjor Types of Collagen |
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Definition
Collagen I Collagen II Collagen III Collagen VI Collagen IV
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Term
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Definition
Most abundant protein in body Same in most species Unique AA's: hydroxylysine, hydroxyproline repeating GLY every 3rd AA triple helix of alpha chains coded by diff genes
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Term
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Definition
Classification: (Fibrillar) - Location: tendon skin, ligament alpha chains: (alpha1)2 and (alpha2)1 |
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Term
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Definition
Classification: Fibrillar Location: Cartilage Alpha Chains: (alpha1)3 |
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Term
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Definition
Classification: Fibrillar Location: Skin vessels, Tendon Alpha Chains: (alpha1)3 |
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Term
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Definition
Classification: Fibrillar Location: Cargilage assoc w/type II Alpha Chains: (alpha1), (alpha2), (alpha3) |
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Definition
Classification: Network Forming Location: Basement Membrane alpha Chains: (alpha1)2, (alpha1) |
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Term
| Connective Tissue Components |
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Definition
Origins: Mesoderm -> Mesenchyme CELLS FIBERS GROUND SUBSTANCE
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Term
4 Cell Types of Connective Tissue |
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Definition
Fibroblast - makes (Collagen I) ligament, tendon, capsules Adipocytes - store fat Chondroblast - cartilage Osteoblast- bone
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Term
3 Types of Fibers In Connective Tissue |
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Definition
Collagen - flexibility and strength Elastic - stretches Reticular - basket around organs
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Term
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Definition
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Term
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Definition
Primary - GLY-X-Y repeated Secondary: alpha chains (1,2,or3) Tertiary&Quartenary: triple helix - 3 alpha chains
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Term
| Melting Point of Collagen |
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Definition
Ratio of Pro + Hyp is directly related to Tm & Ts Tm = temperature at which 50% of helical content is lost. Tm > Tbody |
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Term
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Definition
ER & GOLGI Synthesis of alpha chains Hydroxylation of proline and lysine Glycosylation of select hydroxylysines Assembly into triple Helix using registration peptides
ECM Tropocollagen: Cleavage of registration peptide by procollagen peptidase Collagen Fibril: self-assembly of tropocollagens into a staggered 64nm banding pattern Collagen Fiber: cross-linking of collagen fibrils Bundles of Fibers: tube of collagen I containing many collagen fibers
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Term
Which Collagen Types make Collagen Fibrils |
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Definition
Collagen Type I, II, III, V and VI (makes 64nm banding pattern) |
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Term
Which Collagen Types make Collagen Fibers |
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Definition
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Term
| Which Collagen Types make Bundle of Collagen Fibers? |
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Definition
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Term
| Enzymes in Collagen Synthesis |
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Definition
Prolyl hydroxylase Lysyl hydroxylase Lysyl oxidase - invovled in cross-linking Glycosyl transferase - glycosylation of hydroxyleuscine Amino and arboxyl Terminal Peptidase - ?
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Term
| Precautions with cross linking |
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Definition
–SH groups can react with the aldolhydes and inhibit collagen synthesis because it will react with the aldo groups and form a stable product. |
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Term
| Vitamin C Deficiency in Collagen Synthesis |
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Definition
| Hydroxylation will not occur and the collagen made will be unstable. If collagen is not hydroxylated it will mostly be degraded before it leaves the Golgi |
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Term
| Elastic Fiber - Characteristics |
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Definition
Stretches easily branching fibers very resistant to boiling,acidsm and protease digestion forms clothlike structure in wall of some blood vessels
LOCATION: Loose CT, Elastic CT, Elastic Cartilage, Elastic arteries, ligaments, Dermis |
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Term
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Definition
Microfibrils -fibrillin protein Elastin Fibroblast Cells Smooth Muscle Cells Chondrocytes Cells
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Term
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Definition
80% nonpolar AA (val, ala, leu,ile) Unique AA: desmosine, isodesmosine (4 lysine residues) 33% GlY but not every 3rd
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Term
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Definition
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Term
| Elastin - Location in Body |
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Definition
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Term
| Genetic Markers of Collagen vs Leucine? |
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Definition
Collagen - Lysinonorleucine Elastin - Desomosine and Isodesmosine |
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Term
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Definition
A dietary disease which results in the inactivation of lysyl oxidase causing crosslinking inhibition of collagen by: regular consumption of Beta-aminoproprionitrile found in sweet pea which inactivates lysyl oxidase resulting in decreased crosslinking in collagen. or, penicillamine which inhibits collagen crosslinking because it chelates copper ions that are needed for lysyl oxidase activity. (Used to treat Wilson's disease which is a overload of copper)
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Term
| Which fiber is made of multiple genes |
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Definition
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Term
| Which fiber is found predominantly in the lung and arterial walls? |
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Definition
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Term
| Which fiber contains lysinonorleucine & alsol condensaion crosslinks? |
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Definition
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Term
Which fiber contains desmosine crosslinks? |
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Definition
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Term
| Crosslinking occurs in which fiber type |
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Definition
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Term
| Is structure of elastin helical? |
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Definition
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Term
| Which fiber is more easily destroyed elastin or collagen? |
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Definition
| Collagen, melting point must be above body tempature. Elastin can not be boild and highly resistant to acids. |
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Term
| Glycosylation occurs on which fiber |
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Definition
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Term
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Definition
| a variety of collagen disorders |
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Term
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Definition
| Collagen hydroxylation disorder to due to deficiency in Vitamin C |
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Term
| Collagen Cross-linking Disorders |
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Definition
Menkes Homocysteinuria Lathyrism Ehlers-Danlos V
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Term
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Definition
polyanionic complex that consist of GAGscovalently attached to a core protein |
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Term
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Definition
A long sugar chain of Hyalurinc Acid with proteoglycans attached to it with linker proteins |
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Term
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Definition
Suflated GAG Gluc (S) - Glu (S) |
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Term
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Definition
Suflated GAG Gluc (S) - Glu (S) Less sulfate residues than heparin |
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Term
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Definition
SUlfated GAG Glu (S) - Gal (S) |
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Term
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Definition
SUlfated GAG Glu - Gal (S) |
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Definition
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