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Coagulation
Coagulation flashcards for Test
16
Other
12th Grade
05/28/2009

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Term
Prostoglandins
Definition
secreted by endothelial cells to prevent the formation of platelet plugs and Fibrin Clots
Counteracts constriction by causing vasodilation
inc. bloodflow to area
inhibits activation of platelets
inhibits aggregation of platelets at lower concentration than is necessary to prevent
Term
First response to vessel injury is...
Definition
constriction of the lumen
Term
required for vascular integrity
Definition
a. Functional thrombocytes
b. adequate connective tissue such as collagen and hyaluronic acid
Term
Serotonin
Definition
product of platelet activation
Term
Thromboxane A2
Definition
From platelet activation
Term
Endothelin
Definition
Produced by endothelial cells
Term
regulatory milecules that interact with receptors on the surface of cells of blood vessel walls
Definition
Serotonin
Thromboxane A2
Endothelin
Plasminogen activators
Fibronectin
Term
Plasminogen activators
Definition
Secreted by endothelium; leads to production of plasmin ans degradation of any thrombi that do form
Term
Prostoglandins
(PGI2, Prostocyclin)
Definition
synthesisized and secreted by endothelial cells
Term
Prostoglandins
Definition
Term
Heparin Sulfate
Definition
On Luminal surface; interacts with and potentiates Antithrombin III (A natural circulating anticoagulant),to prevent formation of thrombi.
Term
Thrombomodulin
Definition
Secreted onto endothelial cell membrane where it activates Protein C & Degrades factors V and VIII
Term
PGI2
Definition
Synthesized and secreted by endothelial cells; is vasodilator, inhibits activation of platelets, prevents formation of clots w/i blood vessels
Term
tPA (tissue plasminogen inhibitor)
Definition
PAI-I (plasminogen activator inhibitor) synthesized by endothelial cells are involved in control of fibrinolysis
Term
Glycoprotein IIb/IIIa
Definition
receptor for fibrinogen; also binds fibronectin and vonWillebrand factor
Term
Organelle zone
Definition
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