Term
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Definition
| platelets receptor that binds to VWF |
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Term
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Definition
| activated when Platelets bind to VWF (or by activators ,adp epinephrine,calcium etc.)- binds to fibrinogen, allowly platelet-platelet attachment. These attachments eventually lead to platelet degrandulation. |
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Term
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Definition
| multimeric glycoprotein for platelet-subendothelium adhesion |
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Term
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Definition
| found in alpha granules of plasma and endothelium- nededt o cleave vwf to functional sizes. |
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Term
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Definition
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Term
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Definition
| found in platelets increse activation |
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Term
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Definition
| contain adamts13. other roles such asdelivery ofcoag factors to area. |
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Term
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Definition
| paltelets put in wit hbunch of activators, i.e. adp, epi, calcium and risotecin (antiobitci that causesp latelets to aggregate in the presence of VFW). More aggregation - more light transmission . Regarded as best test for paltelet funciton but hardt o use. |
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Term
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Definition
| extrinsinsic pathway measure |
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Term
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Definition
| intrinsince pathway meaure. |
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Term
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Definition
| In presence of TF activates IX and X |
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Term
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Definition
| in presence of V activates Thrombin |
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Term
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Definition
| activates fibrinogen to fibrin. Also activates 5,8,9,10,11 |
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Term
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Definition
| alogn with factor VIII, activates factor X |
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Term
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Definition
| ,activated by thrombin. activates factor iX |
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Term
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Definition
| 2,7,9,10- require vitamin k. |
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Term
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Definition
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Term
| factor sites of production |
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Definition
| all factors in liver ExCEPT factor VIII. Factor VIII is made in endothelial celsl with VWF. |
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Term
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Definition
| not measured by PTT or PT. activated by thrombin, crosslinks fibrin, without it clots dissolve much faster |
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Term
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Definition
| fibrinogen resistance to activation by thrombin or cross linking . Patients havedelayd bleeidgn afteri njury or surgery. PT and pTT remain normal, though Thrombin time may change. Also may result in thrombosis, if mutated fibrinogen is resistant to lysis. |
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Term
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Definition
| on endothelial surface, cofactor for antithrombin |
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Term
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Definition
| autosomal dominant. Heparan is uselless. Incidence of homoygosity basically elthal- neonatal purpura fulminans. |
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Term
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Definition
| expressed by endothelial cells- binds to thrombin, changing its conformation so it does not work. This complex required for protein C activation. |
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Term
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Definition
| Protein C and S are vitamin dependant inhibitors of procoagulance, both synthed in liver! Protein C is a zymogen activated by thrombin-thrombomodulin. Protein C turns off V and VIII. |
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Term
| Protein S and Protein C defieicny |
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Definition
| autosomal dominant. Homozygouz infants present with life threatenign purpura . Increased fibrinogenylisis, Warfarin idnuced skin necrosis. |
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Term
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Definition
| change in conformation of Factor V so that Va is resistant to cleave by activated Protein C - fialure to prolong ptt. Arg-> glutamine mutation |
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Term
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Definition
| egative regulator of TF-VII complex, so may be used anticoagulant. Also kncoked out x |
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Term
| prothrombin gene mutation |
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Definition
| higher circulating prothrombin in circulation. due to 3 prime mutation in gene which leadsto more stable prothrombin |
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Term
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Definition
| degrades fibrin clots, serine protease that is initially the zymogen plasminogen. Degrades fibrin to Fibrin split product. |
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Term
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Definition
| convert plamisnogen to plasmin. Released by endothelium- stimulated by fibrin. |
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Term
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Definition
| convert plamsminogen to plasmin. |
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Term
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Definition
| once clots are broken down, all that is left is sall fibrin covalent crosslinks known as d- dimers. |
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Term
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Definition
| tpA inhibitor. So deficiency leads to bleeding. |
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Term
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Definition
| svanges free circulating plasmi. Deficiency is a bleedign disorder. |
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Term
| Mechanism of granule secetion: |
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Definition
| phospholipid driven- collagen binding initiates arachidonic acid conversion to thromboxane a2, by cox-1. |
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Term
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Definition
| Protein S has no activity but is rquire or protein C to work. Can be bound or free. 50 percent boudn to c4b (complement ,so when inflammation is incrased moreof protein s is sequestered). |
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Term
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Definition
| synthed in liver and normal endothelial cells, ianctivated thrombin , 9-12-check |
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Term
| stimulus for platelet degranulation |
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Definition
| binding of fibrinogen to receptorf |
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Term
| platelet function analyzer |
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Definition
| place paltelet activators alogn a glass tue, pour platelets in and see hwo logn it takes for clot to form over aperture. Good test for VWF, and for severe platelet dysfunction, though mild disroders wil lbe missed. Also may be affected by aspirin. |
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Term
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Definition
| bp pupped to 40 mm , a cut is madei narm to se hwo logn bleeign stops. |
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Term
| first reaction of blodo vessel to damage what activates thrombois |
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Definition
| blood vessel constircts, and subendohelium is exposed which has vwf, collagen tf, etc. on it. |
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Term
| platelet receptors expression factors |
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Definition
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Term
| clotting cascade location |
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Definition
| surface of activated platelet and dmaged endothelium. Phospholipids on platelet wall provide the itneraction sruface or clotting. |
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Term
| Plasminogen how it getstoclot |
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Definition
| is already bound to fibrinogen, so is present in clot as iwtis formed. |
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