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Coagulation
Part 4
19
Nursing
Graduate
11/06/2014

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Cards

Term
IN THE COAGULATION CASCADE THROMBIN ACTIVATE WHAT 3 MAIN THINGS?
Definition
PLTS, FIBRINOGEN TO FIBRIN, AND FACTORS 13,5,8,4(CALCIUM)
Term
WHAT LIMITS COAGULATION BY LIMITING THE AMOUNT OF TIME PLTS SPEND NEAR THE DAMAGED SITE?
Definition
FLOW OF BLOOD
Term
WHAT 4 MECHANISMS PLAY A REGULATORY ROLE IN COAGULATION?
Definition
FIBRINOLYSIS, TISSUE FACTOR PATHWAY INHIBITOR (TFPI) WHICH INHIBITS 1ST STEP OF EXTRINSIC PATHWAY, PROTEIN C SYSTEM, AND SERINE PROTEASE INHIBITORS.
Term
DURING FIBRINOLYSIS WHAT IS ACTIVED BY TPA FROM THE VASCULAR ENDOTHELIUM?
Definition
PLASMINOGEN
Term
WHAT IS ACTIVATED PLASMINOGEN CALLED?
Definition
PLASMIN
Term
WHAT DOES PLASMIN DO?
Definition
DEGRADES FIBRIN AND FIBRINOGEN, INHIBITS COFACTORS V AND VIII, AND REDUCES PLT GLYCOPROTEIN SURFACE RECEPTORS
Term
DOES PLASMIN CIRCULATE EVERYWHERE?
Definition
NO (WOULD LEAD TO DIFFUSE BLEEDING). PLASMIN IS A LOCAL OCCURENCE.
Term
WHAT DOES TISSUE FACTOR PATHWAY INHIBITOR DO?
Definition
INHIBITS THE TISSUE FACTOR/FACTOR VIIA COMPLEX. THIS IS THE FIRST STEP OF THE EXTRINSIC PATHWAY.
Term
WHAT DOES PROTEIN C DO?
Definition
IT INHIBITS THROMBIN AND COFACTOR VA AND VIIIA.
Term
PROTEIN C IS ACTIVATED BY WHAT?
Definition
THROMBOMODULIN (WHICH BINDS TO AND REMOVES THROMBIN)
Term
WHAT PROTEIN DOES PROTEIN C COMBINE WITH?
Definition
PROTEIN S. BOTH PROTEIN C AND PROTEIN S ARE VITAMIN K DEPENDENT FACTORS
Term
SERINE PROTEASE INHIBITOS THINK WHAT?
Definition
HEPARIN
Term
WHAT 2 FACTORS ARE ASSOCIATED WITH ANTITHROMBIN?
Definition
ANTITHROMBIN (ANTITHROMBIN III) AND HEPARIN COFACTOR II
Term
WHAT DOES ANTITHROMBIN BIND TO AND INHIBIT?
Definition
THROMBIN (IIA), IXA, XA, XIA, AND XIIA.
Term
ACQUIRED ANTITHROMBIN DEFICIENCY (MORE CLOTS) OCCURS IN WHAT 8 DISEASES/STATES?
Definition
LIVER DISEASE, PROLONGED HEPARIN ADMINISTRATION, NEPHROTIC SYNDROME, DIC, SEPSIS, PREECLAMPSIA, ORAL CONTRACEPTIVE USE, AND DURING CARDIOPULMONARY BYPASS
Term
WHAT INHIBITS THROMBIN?
Definition
HEPARIN COFACTOR II
Term
WHAT DRUG ACCELERAT ANTITHROMBIN ACTIVITY?
Definition
HEPARIN
Term
GP-IB IS IN PLTS AND WHAT BINDS TO THAT?
Definition
VWF WHICH INITIATION OF PLT CROSS BRIDGING.
Term
GP-IIB/IIIA IS IN PLTS AND WHAT BINDS TO THAT?
Definition
FIBRINOGEN TO FORM THE PLT PLUG
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