Term
| NORMALLY THE ENDOTHELIUM IS AN ANTITHROMBOTIC SURFACE THAT POSSESSED WHAT 3 THINGS? |
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Definition
| ANTIPLATELET, ANTICOAGULANT, AND PROFIBRINOLYTIC EFFECTS (BREAK DOWN CLOTS) |
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Term
| DOES THE VASCULAR ENDOTHELIUM REPEL PLATELTS TO KEEP BLOOD FREE FLOWING? |
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Definition
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Term
| NAME 2 ENDOTHELIAL VASODILATORS AND PLATELET INHIBITORS. |
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Definition
| NITRIC OXIDE AND PRASTACYCLIN |
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Term
| WHAT SUBSTANCE IS SYNTHESIZED IN THE VASCULAR ENDOTHELIUM, WHICH ACTIVATES FIBRINOLYSIS? |
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Definition
| TISSUE PLASMINOGEN ACTIVATOR |
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Term
| AFTER VASCULAR ENDOTHELIAL INJURY WHAT 3 MAIN THINGS HAPPEN? |
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Definition
| VASOSPASM (PART NEUROGENIC AND PART ENDOTHELIAL MEDIATED) PRIMARY HEMOSTASIS (FORMATION OF A PLATELET PLUG (WHITE CLOT), AND SECONDARY HEMOSTASIS (FORMATION OF A CLOT (RED CLOT) |
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Term
| WHAT OCCURS IMMEDIATELY AFTER VASCULAR INJURY? WHAT IS IT MEDIATED BY? |
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Definition
| VASOCONSTRICTION. ENDOTHELIN |
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Term
| VASOCONSTRICTION IS TRANSIENT. WHAT DOES THAT MEAN? |
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Definition
| IF PRIMARY HEMOSTASIS DOESN'T OCCUR, BLEEDING RESUMES. |
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Term
| WHERE ARE PLATELETS DERIVED FROM? WHAT ARE THEY ALSO CALLED? |
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Definition
| BONE MARROW. ALSO KNOWN AS THROMBOCYTES |
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Term
| WHAT IS THE SHAPE OF PLTS? |
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Definition
| NORMALLY CIRCULATE AS INACTIVATED DISCS |
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Term
| WHAT DOES PLTS CONTAIN ON THEIR CELL SURFACE? |
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Definition
| PLTS CONTAIN GLYCOPROTEIN RECEPTORS ON THE MEMBRANE SURFACE. THEY ALSO CONTAIN MEDIATORS AND CHEMICALS INSIDE THE PLTS. |
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Term
| WHAT ARE HALF LIFES OF PLTS? |
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Definition
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Term
| HOW DOES PLTS GET REMOVED? |
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Definition
| FROM MACROPHAGES IN THE SPLEEN. |
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Term
| PLTS UNDERGO A 3 STEP CASCADE THAT FORMS A PLT PLUG IN ORDER TO INITIALLY STOP BLEEDING. WHAT ARE THEY? |
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Definition
| ADHESION, ACTIVATION, AGGREGATION |
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Term
| AFTER INJURY OF A VESSEL SUBENDOTHELIAL FACTORS ARE EXPOSED. WHAT IS SECRETED BY THE INJURED VESSEL? |
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Definition
| VON WILLEBRAND FACTOR (vWF) |
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Term
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Definition
| GLYCOPROTEIN IB RECEPTOR ON THE PLT MEMBRANE |
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Term
| AFTER VWF BINDS TO THE PLTS ON THE GP-1B WHAT DOES THE VWF DO TO THE PLTS? |
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Definition
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Term
| AFTER VWF MAKES PLTS STICKY WHAT DOES THAT RESULT IN? |
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Definition
| THIS FORMS A BRIDGE AND ATTACHES THE PLTS TO THE COLLAGEN OF THE SUBENDOTHELIUM. |
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Term
| WHAT IS THE 2ND PHASE OF PRIMARY HEMOSTASIS? |
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Definition
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Term
| AFTER THE PLTS ADHERE TO THE VESSEL WALL, IT BECOMES ACTIVATED BY WHAT? |
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Definition
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Term
| WHAT HAPPENS TO THE PLTS AFTER THROMBIN COMES INTO THE PICTURE? |
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Definition
| THE PLTS CHANGE SHAPE. TRANSFORMING IT FROM THE DISCOID SHAPE TO A MORE FLAT PANCAKE SHAPE WITH MULTIPLE PROTRUSIONS. THIS GREATLY INCREASES THE SURFACE AREA OF THE MEMBRANE. |
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Term
| WHAT 6 COAGULATION FACTORS DOES PLTS CONTAIN? |
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Definition
| ADP, ATP, CALCIUM, SEROTONIN, HISTAMINE, AND EPI. THESE ARE RELEASED UPON ACITVATION. |
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Term
| DURING ACTIVATION AFTER PLTS CHANGE IN SHAPE WHAT IS RELEASED? |
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Definition
| PLT PHOSPHOLIPASE A2 IS ACTIVATED (PLA2) |
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Term
| PLA2 CAUSES RELEASE OF WHAT? |
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Definition
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Term
| WHAT DOES THROMBOXANE A2 (TXA2) RESULT IN? |
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Definition
| VASOCONSTRICTION AND ACTIVATES NEARBY PLTS (POSITIVE FEEDBACK) |
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Term
| ARACHIDONIC ACID IS CONVERTED TO WHAT BY WHAT? |
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Definition
| THROMBOXANE A2 BY CYCLOOXYGENASE |
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