Term
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Definition
| Receptor on platelet membrane that binds to Von Willebrand factor on endothelium |
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Term
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Definition
| Protein synthesized by megakaryocytes and endothelial cells that polymerize on the subendothelium |
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Term
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Definition
| Cleaves platelet membrane phospholipid to give arachidonic acid |
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Term
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Definition
| Cleaved from platelet membrane phospholipid and is formed into cyclic endoperoxide and prostacyclin by cyclic oxygenase |
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Term
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Definition
| Formed from arachidonic acid by cyclic oxygenase and upregulates cAMP to decrease calcium levels and inhibit platelet adhesion |
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Term
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Definition
| Formed from arachadonic acid by cyclic oxygenase and is converted to thromboxane A2 by thromboxane synthetase |
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Term
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Definition
| Activates phospholipase C |
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Term
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Definition
| Cleaves phosphatidylinositol-bisphosphate to diacylglycerol and inositol triphosphate |
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Term
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Definition
| Activate protein kinase C |
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Term
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Definition
| Activates IIb/IIIa and increases phospholipase A2 synthesis |
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Term
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Definition
| Comes from phosphatidylinositol-bisphosphate and increases intracellular calcium |
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Term
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Definition
| Receptor on the platelet membrane that is activated by protein kinase C; binds to fibrinogen |
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Term
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Definition
| Activated by VIIa/TF (intrinsic) or IXa/VIIIa (extrinsic), inhibited by antithrombin, converts prothrombin (factor II) to thrombin (factor IIa) with cofactor Va |
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Term
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Definition
| Factor X is activated by VIIa and TFPa |
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Term
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Definition
| Initiated by XII, factor X is converted to factor Xa by factor IXa and VIIIa |
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Term
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Definition
| Measures the amount of time taken for coagulation pathway to complete; measures extrinsic pathway and is insensitive to factor VIII |
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Term
| Partial thromboblastin time (PTT) |
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Definition
| Measures coagulation efficiency of the intrinsic pathway; sensitive to factor VIII |
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Term
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Definition
| Converted by factor Xa and Va to thrombin |
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Term
| Which coagulation test do you use to monitor warfarin effects on coagulation? |
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Definition
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Term
| Which coagulation test do you use to monitor heparin affects on coagulation? |
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Definition
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Term
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Definition
| Cleaves fibrinogen to fibrin, activates factors V, VIII, XIII, actives protein C, |
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Term
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Definition
| Converted to fibrin by thrombin, allows platelet aggregation when bound by gp IIb/IIIa |
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Term
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Definition
| Acts as a cofactor with factor X to convert prothrombin (factor II) to thrombin (factor IIa); activated by thrombin and inactivated by plasmin and protein C |
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Term
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Definition
| Acts with tissue factor to activate either factor X or factor IX; inhibited by tissue factor pathway inhibitor (TFPI) |
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Term
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Definition
| Activated by thrombin, inactivated by plasmin and protein C, cofactor with factor IX in factor X activation |
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Term
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Definition
| Works with cofactor VIII to convert factor X to Xa |
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Term
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Definition
| Initiates the intrinsic coagulation pathway |
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Term
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Definition
| Activated by thrombin, stabilizes fibrin clot |
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Term
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Definition
| Causes transient vasodilation and platelet inhibition; upregulates guanylate cyclase |
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Term
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Definition
| Serine protease inhibitor that prevents coagulation by directly binding thrombin and/or factor Xa |
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Term
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Definition
| Binds to antithrombin to increase its activity |
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Term
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Definition
| Activated to APC by thrombin; binds to and degrades factors Va and VIIIa with cofactor protein S |
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Term
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Definition
| Normally bound to compliment C4b in serum; acts as a cofactor in APC inactivation of factors Va and VIIIa |
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Term
| Tissue factor pathway inhibitor (TFPI) |
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Definition
| Enzyme inhibitor that binds to VIIa and Xa to prevent VIIa interaction with TF--inhibits the conversion of prothrombin to thrombin |
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Term
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Definition
| Cleaved from plasminogen by tissue plasminogen activator when bound to fibrin; cleave fibrin into D dimers to break up clotsUro |
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Term
| tPA (tissue plasminogen activator) |
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Definition
| Cleaves plasminogen to plasmin, inhibited by plasminogen activator inhibitor-1 (PAI-1) |
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Term
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Definition
| Cleaves plasminogen into plasmin without the presence of fibrin |
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Term
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Definition
| Binds to plasmin in the serum (unbound to clot) |
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