Term
| What is the mechanism of Heparin's anticoagulation effect? |
|
Definition
| Heparin binds Antithrombin III -> increasing its affinity for clotting factors -> Inactivates Factors |
|
|
Term
| What can occur in patients that are on heparin for 5-10 days? |
|
Definition
Heparin-induced Thrombocytopenia (HIT)
Antibodies form against Heparin-PF4 complex -> activate platelets to form clots -> more PF4 released -> reacts with heparin PF4 complexes on endothelial cells -> destroys endothelial cells |
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|
Term
| What drug blocks the reactivation of Vitamin K, by binding epoxide reductase? |
|
Definition
|
|
Term
| What factors require activation by vitamin K? |
|
Definition
|
|
Term
| What can the delayed onset of Warfarin cause? |
|
Definition
| increased clotting due to a procoagulant effect |
|
|
Term
| What is the indications for Warfarin use? |
|
Definition
Deep vein thrombosis
Pulmonary embolism
Arterial fibrillation
Rheumatic heart disease
Mechanical and prosthetic heart valves |
|
|
Term
| What are the Direct Thrombin Inhibitors? |
|
Definition
Hirudin
Lepirudin - recombinant hirudin
Argatroban
Melagatran |
|
|
Term
| What is found in the salivary glands of the medical leech? |
|
Definition
Hirudin
Direct Thrombin inhibitor |
|
|
Term
| How do the Direct Thrombin inhibitors work? (Hirudin, Bivalirudin, Argatroban) |
|
Definition
Specific and potent inhibitor of thrombin
Inhibits thrombin-mediated activation of clotting factors (V,VIII, XI, XIII) and platelets |
|
|
Term
| Can Direct Thrombin inhibitors induce immune-mediated thrombocytopenia? |
|
Definition
|
|
Term
| What Thrombin inhibitors can be administered Subcutaneously? |
|
Definition
Recombinant Hirudins
Argatroban |
|
|
Term
| What anticoagulant drugs are have effect on both circulating and clot-bound thrombin? |
|
Definition
Direct Thrombin Inhibitors
(Hirudins, Bivalirudin, Argatroban |
|
|
Term
| What Direct Thrombin Inhibitors would be appropriate for a patient with Renal disease? |
|
Definition
|
|
Term
| What is the Acute and Chronic Therapy for Venous Thrombosis? |
|
Definition
Acute - Heparin
Chronic - Warfarin |
|
|
Term
| What is the acute and chronic therapy for TIA, Thrombotic Stroke? |
|
Definition
Acute - Heparin, Aspirin
Chronic - Aspirin, Clopidigrel |
|
|
Term
Acute and Chronic Therapy
Unstable angina |
|
Definition
Acute - Heparin, Aspirin, GPIIb/IIIa inhibitors
Chronic - Aspirin, Clopidigrel |
|
|
Term
Acute and Chronic Therapy
Myocardial Infarction |
|
Definition
Acute - Thrombolytic, Heparin, Aspirin
Chronic - Aspirin |
|
|
Term
Acute and Chronic Therapy
Atrial Fibrillation |
|
Definition
Acute - Heparin
Chronic - Warfarin |
|
|
Term
Acute and Chronic Therapy
Angioplasty/Stent |
|
Definition
Acute - Heparin, GPIIb/IIIa inhibitors
Chronic - Aspirin, Clopidigrel |
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