Shared Flashcard Set

Details

Coagulation Cascade - DIC
DIC
8
Medical
Undergraduate 2
03/22/2012

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Cards

Term
Disseminated Intravascular Coagulation
Definition

thrombin and/or plasmin produce at a rate that exceeds their natural inhibitors to neutralize

 

circulate in vascular system and activate coagulation and fibrinolytic proceses

 

clotting and bleeding occur

 

acquired disease

Term
DIC Characterization
Definition

consumption of coagulation factors and platelets

 

generation of thrombin

 

widespread deposits of fibrin in small vessels

Term
DIC Etiology
Definition
primary disease introduces tissue factor or tissue factor-like substances into circulation
Term
DIC Clinical Conditions
Definition

infections

 

production of endotoxoins and/or generation of cytokines

 

Term
DIC Symptoms
Definition

renal failure

coma

liver failure

respiratory failure

skin necrosis, gangrene

venous thromboembolism

mortality in 50 - 60% cases

Term
DIC Laboratory Results
Definition

decreased platelet count 40-75 x 109/L due to thrombin activation and clearance

prolonged PT and APTT due to reduction of clotting factors

decreased factors II, V, VIII, X

decrease in fibrinogen due to conversion of fibrin monomer and fibrin

increase in FDP due to secondary lysis of fibrinogen and fibrin

Term
DIC Laboratory Diagnosis
Definition

90% certain when PT, fibrinogen, and platelet count are abnormal

 

or

 

two of the three tests are abnormal with an elevated fibrin degradation products (FDP)

Term
DIC Treatment
Definition

eliminate the primary condition

 

DIC with bleeding requires replacement therapy

 

DIC with thromboemboli requires heparin

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