Term
|
Definition
1. benzo; facilitate GABA via ↑ FREquency of Cl-Ch opening {Short acting, a "TOM thumb"}
2. anesthesia inducing
3. Dependence/Withdrawal; with ETOH = additive sedation effects |
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Term
|
Definition
1. benzo; facilitate GABA via ↑ FREquency of Cl-Ch opening
2. insomnia
3. Dependence/Withdrawal; with ETOH = additive sedation effects |
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Term
|
Definition
1. benzo; facilitate GABA via ↑ FREquency of Cl-Ch opening {Short acting, a "TOM thumb"}
2. insomnia
3. Dependence/Withdrawal; with ETOH = additive sedation effects |
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Term
|
Definition
1. benzo; facilitate GABA via ↑ FREquency of Cl-Ch opening
2. anxiety
3. Dependence/Withdrawal; with ETOH = additive sedation effects |
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Term
|
Definition
1. benzo; facilitate GABA via ↑ FREquency of Cl-Ch opening
2. anxiety; Status Epilepticus, generalized seizures
3. Dependence/Withdrawal; with ETOH = additive sedation effects |
|
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Term
|
Definition
1. benzo; facilitate GABA via ↑ FREquency of Cl-Ch opening {Short acting, a "TOM thumb"}
2. anxiety
3. Dependence/Withdrawal; with ETOH = additive sedation effects |
|
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Term
|
Definition
1. benzo; facilitate GABA via ↑ FREquency of Cl-Ch opening
2. insomnia
3. Dependence/Withdrawal; with ETOH = additive sedation effects |
|
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Term
|
Definition
1. benzo; facilitate GABA via ↑ FREquency of Cl-Ch opening
2. anxiety
3. Dependence/Withdrawal; with ETOH = additive sedation effects |
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Term
|
Definition
1. benzo; facilitate GABA via ↑ FREquency of Cl-Ch opening
2. anxiety, status epilepticus, generalized seizures
3. Dependence/Withdrawal; with ETOH = additive sedation effects |
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Term
|
Definition
1. benzo GABA competitive antagonist
2. to tx benzo toxicity/overdose
3. can cause Benzo withdrawl sydrome; t1/2life = 30-60 mins |
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Term
|
Definition
1. partial 5-HT1 & 5-HT2 receptor agonist
2. Long term anxiolytic (but long latency until effective)
3. agitation; Serotonin Syndrome |
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Term
|
Definition
1. non-benzo GABA receptor agonist
2. insomnia
3. anterograde amnesia, odd sleep behaviors |
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Term
|
Definition
1. non-benzo GABA receptor agonist
2. insomnia
3. anterograde amnesia, odd sleep behaviors |
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Term
|
Definition
1. non-benzo GABA receptor agonist
2. insomnia
3. anterograde amnesia, odd sleep behaviors |
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Term
|
Definition
1. melatonin receptor agonist
2. insomnia - aids in ONSET of sleep
3. elevate PRL levels; CONTRA to depression pts |
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Term
|
Definition
1. stabilize inactive Na-Ch; inhibit Ca-Ch; Enzyme INDUCER
2. localization epilepsy; Trigeminal Neuralgia 1st line tx; Manic bipolar
3. epoxide metabolite = headaches, GI = limits rapid titration |
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Term
|
Definition
1. stabilize inactive Na-Ch; inhibit Ca-Ch; Enzyme INDUCER
2. localization epilepsy |
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Term
|
Definition
1. inhibit T-type Ca-Ch
2. Absence only!
3. rash, SJS |
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Term
|
Definition
1. inhibit Ca-Ch; enhance GABA synthesis but NO ACTION on GABA-R
2. Partial/T-C Seizures; post-herpetic neuralgia; bipolar; periph neuropathy
3. nausea, somnolence, lightheaded
4. minimal interactions, excreted in urine |
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Term
|
Definition
1. inhibit Ca-Ch; enhance GABA transport but NO ACTION on GABA-R
2. localization; neuropathic pain
3. slightly more potent = slightly more effects
4. minimal interactions, excreted in urine |
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Term
|
Definition
1. binds CRMP cell proteins needed for ion trafficking and neuronal sprouting; stabilize inactive Na-Ch
2. combo tx for localization
3. prolong PR = 1st degree AV block |
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Term
|
Definition
1. stabilize inactive Na-Ch (inhibit Ca-Ch inhibits glutamate release)
2. lennox-gastaut generalized
3. Severe, life-threatening RASH
4. t1/2 signif increased with Valproate, shortened with other AEDs |
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Term
|
Definition
1. inhibit Ca-Ch; interacts with unique synaptic vesicle proteins
2. localization & some generalized
3. behavioural probs
4. plays well with other drugs! |
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Term
|
Definition
1. prolongs DURATION of time GABA is open (inhibit Ca-Ch; inhibit NMDA glutamate) LONG t1/2 = 60-110 hrs!
2. sedative for anxiety, seizure, insomnia; epilepsy - 1st line in pregnancy and kids
3. rash, depression, behavioural
4. Enzyme INDUCER |
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Term
|
Definition
1. stabilize inactive Na-Ch;
2. status epilepticus & T-C seizures
3. nystagmus, ataxia, gingival hyperplasia; ↓folate absorpt = megaloblast-anemia; TERATOGEN
4. Enzyme INDUCER and ZERO ORDER kinetics |
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Term
|
Definition
1. inhibit GABA reuptake
2. localization |
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Term
|
Definition
1. potentiate GABA at own unique site; stabilize inactive Na-Ch; inhibit Ca-Ch; inhibit glutamate
2. localized, generalized; Migraines
3. risk for cleft palate defects; psychomotor slowing, parasthesias, kidney stones; WEIGHT LOSS |
|
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Term
|
Definition
1. potentiate GABA at own unique site; stabilize inactive Na-Ch; inhibit Ca-Ch; inhibit glutamate
2. localized, generalized; Migraines
3. risk for cleft palate defects; psychomotor slowing, parasthesias, kidney stones; WEIGHT LOSS |
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Term
|
Definition
1. promotes GABA synthesis, inhibitis GABA metobo; stabilize inactive Na-Ch; inhibit Ca-Ch
2. localized, generalized, ABSCENCE, Migraines
3. Weight GAIN, tremor, hair loss; risk for NTDs
4. ENZYME INHIBITOR (esp lamotrigine) |
|
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Term
|
Definition
1. Low Potency Typical Antipsychotic; blocks dopamine receptors
2. Psychosis/Schizophrenia
3. Malignant Neuroleptic Syndrome, EPS, Tardive Dyskinesia Anticholinergic & adrenergic effects, Endocrine disturbances
{NMS - tx with dantrolene or bromocriptine |
|
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Term
|
Definition
1. Low Potency Typical Antipsychotic; blocks dopamine receptors
2. Psychosis/Schizophrenia
3. Malignant Neuroleptic Syndrome, EPS, Tardive Dyskinesia Anticholinergic & adrenergic effects, Endocrine disturbances
{NMS - tx with dantrolene or bromocriptine |
|
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Term
|
Definition
1. HIGH Potency Typical Antipsychotic; blocks dopamine receptors
2. Psychosis/Schizophrenia
3. Malignant Neuroleptic Syndrome, EPS, Tardive Dyskinesia Anticholinergic & adrenergic effects, Endocrine disturbances
{NMS - tx with dantrolene or bromocriptine |
|
|
Term
|
Definition
1. HIGH Potency Typical Antipsychotic; blocks dopamine receptors
2. Psychosis/Schizophrenia
3. Malignant Neuroleptic Syndrome, EPS, Tardive Dyskinesia Anticholinergic & adrenergic effects, Endocrine disturbances
{NMS - tx with dantrolene or bromocriptine |
|
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Term
|
Definition
1. Atypical Antipsychotic(spectrum of actions; Strong 5HT2 antag and NO EPS
2. parkinson patient
3. Severe Agranulocytosis |
|
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Term
|
Definition
1. Atypical Antipsychotic(spectrum of actions; Partial Agonist at 5HT1 and D2, antag at 5HT2
2. milder antichol. - better if you want less sedation |
|
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Term
|
Definition
1. Atypical Antipsychotic(spectrum of actions; 5HT2 > D
3. Weight Gain, can induce DM and hyperglycemia; more antichol. |
|
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Term
|
Definition
1. Atypical Antipsychotic(spectrum of actions; potent a-adrenergic antagonism
3. ABUSE potential, orthostatic hypertension, tachycardia, weight gain |
|
|
Term
|
Definition
1. Atypical Antipsychotic(spectrum of actions; STRONG 5HT2 and D2 action
3. More likely to have EPS and ↑ PRL!; prolongs QT, weight gain |
|
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Term
|
Definition
1. Atypical Antipsychotic(spectrum of actions; also an SSRI!
2. depression patients with psychosis
3. Prolong QT, but NO WEIGHT GAIN! |
|
|
Term
|
Definition
1. Muscarinic anticholinergic
2. Parkinsons, esp early on, helps with tremor and rigidity; Dystonia
3. Atropine-like (dry mouth, |
|
|
Term
|
Definition
1. Muscarinic anticholinergic
2. Parkinsons, esp early on, helps with tremor and rigidity
3. Atropine-like (dry mouth, |
|
|
Term
|
Definition
1. make use of actions: antimuscarinic, enhance dopamine release, block dopamine reuptake, glutamate receptor antagonism
2. Early IPD, dyskinesias in late IPD
3. Livedo reticularis! |
|
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Term
|
Definition
1. selective MAOI TypeB
2. IPD
3. amphetamine-like metabolite (insomnia), confusion
4. Selective so won't cause Wine&Cheese rxn |
|
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Term
|
Definition
1. IRREVERSIBLE selective MAOI TypeB
2. IPD
3. unknown |
|
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Term
|
Definition
1. Dopamine Agonist Ergot Derivative
2. Now 1st Line in Parkinsons; to tx Neuroleptic Malignant Syndrome
3. SLEEP ATTACKS, Retroperitoneal Fibrosis, Raynauds, hallucinations, dyskinesias, GI distress, hypotension |
|
|
Term
|
Definition
1. Dopamine Agonist, Non-Ergot
2. Now 1st Line in Parkinsons
3. like bromo + brings out compulsive behaviours! |
|
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Term
|
Definition
1. Dopamine Agonist, Non-Ergot
2. Now 1st Line in Parkinsons
3. like bromo + brings out compulsive behaviours! |
|
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Term
|
Definition
1. Dopamine Agonist + carbidopa blocks peripheral dopa-decarboxylase
2. Mainstay IPD tx but pt must still have nigra cells left, shortest t1/2
3. GI, Hypotension, hallucinations, dyskinesias, motor flux
4. High PRO diet interferes- a saturable AA transportor needed for Levo absorption |
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Term
|
Definition
1. COMT inhibitor peripherally
2. with levodopa to incr t1/2 by 50%
3. turns urine orange! + effects of incr dopamine |
|
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Term
|
Definition
1. non-narcotic morphine derivative that's a dopamine agonist
2. Rescue tx given Subcu injec.
3. Severe GI rxn (give anti-emetics) |
|
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Term
|
Definition
| betablocker helpful in Essential tremors |
|
|
Term
|
Definition
| barbiturate helpful in essential tremors |
|
|
Term
|
Definition
| GABA agonist helpful in essential tremors |
|
|
Term
|
Definition
1. benzodiazepine
2. essential tremors, dystonia |
|
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Term
|
Definition
benzodiazepine
2. essential tremors, dystonia |
|
|
Term
|
Definition
1. GABA-B agonist
2. dystonia
3. Sedation; rapid dis-use can cause seizures or acute psychosis |
|
|
Term
|
Definition
1. BotoxA binds SNAP-25, BotoxB bind synaptobrevin
2. dystonia
3. muscle weakness |
|
|
Term
|
Definition
1. Irreversible MAOI
2. depression
3. Wine&Cheese, Serotonin Sydrome (pupils dilate, hypertherm, hyperReflex), Risk of Suicide
4. Tons, its metabolized via CYPs |
|
|
Term
|
Definition
1. Tertiary TCA; blocks 5HT reuptake > NE uptake
2. Depression, Fibromyalgia & Insomnnia
3. Anticholinergic (Urinary Retention); QT intv, Suicide Risk, weight gain |
|
|
Term
|
Definition
1. Tertiary TCA; blocks 5HT reuptake > NE uptake
2. Depression, kids with ENURESIS
3. Anticholinergic (Urinary Retention); QT intv, Suicide Risk, weight gain |
|
|
Term
|
Definition
| 1. Secondary TCA; blocks NE reuptake > 5HT uptake 2. Depression, Fibromyalgia 3. Anticholinergic (Urinary Retention); QT intv, Suicide Risk, weight gain |
|
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Term
|
Definition
1. Secondary TCA; blocks NE reuptake > 5HT uptake
2. Depression
3. Anticholinergic (Urinary Retention); QT intv, Suicide Risk, weight gain |
|
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Term
|
Definition
1. SSRI (also inhibit CYPs)
2. also for Premenstrual syndrome
3. Can Precipitate a bipolar's MANIC EPISDOE, Suicide Risk, Serotonin Syndrome |
|
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Term
|
Definition
1. SSRI (also inhibit CYPs)
2. also for Premenstrual syndrome
3. Can Precipitate a bipolar's MANIC EPISDOE, Suicide Risk, Serotonin Syndrome |
|
|
Term
|
Definition
1. SSRI
2. also for Premenstrual syndrome
3. Can Precipitate a bipolar's MANIC EPISDOE, Suicide Risk, Serotonin Syndrome |
|
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Term
|
Definition
1. SSRI
2. also for Premenstrual syndrome
3. Can Precipitate a bipolar's MANIC EPISDOE, Suicide Risk, Serotonin Syndrome |
|
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Term
|
Definition
1. SNRI; blocks 5HT > NE
2. also for anxiety disorders
3. Suicide risk, serotonin syndrome; dry mouth, insomnia, sex-dysfx |
|
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Term
|
Definition
1. SNRI; blocks 5HT ~ NE
2. also for fibromyalgia & diabetic neuropathic pain
3. Suicide risk, serotonin syndrome; dry mouth, insomnia, sex-dysfx |
|
|
Term
|
Definition
1. Atypical; seems to block reuptake of NE and dopamine
2. decr nicotine cravings + minimal sexual side effects!
3. lowers seizure threshold, Suicide Risk |
|
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Term
|
Definition
1. Atypical; blocks a2-adrenergics = incr NE transmission, 5HT2-3 antagonist, and antihistamine action
2. anti-emesis, anti-pruitis
3. increased appetite (good for some elderly) |
|
|
Term
|
Definition
1. atypical; weakly inhibit 5HT uptake, antag to 5HT1 presynaptic autoreceptors, antag to postsynaptic 5HT2 receptors
2. insomnia! (sedating side effect)
3. orthostatic hypotension; metabolized in 2 phases |
|
|
Term
|
Definition
1. element; seems to affect phospholipids- PIP2 recycling = impedes signals from NE, Ach, and serotonin
(no effect on normal ppl)
2. Bipolar
3. TERATOGEN! DI (blocks ADH receptors), convulsions, tremors, arrhythmia, leukocytosis
4. High Na-intake promotes excretion, Thiazide diuretics inhibit excretion=potential for toxicity |
|
|
Term
|
Definition
1. Antiepileptic Drug - "Mood Stabilizer"
2. can be used in bipolar |
|
|
Term
|
Definition
1. Antiepileptic Drug - "Mood Stabilizer"
2. can be used in bipolar |
|
|
Term
|
Definition
1. Antiepileptic Drug - "Mood Stabilizer"
2. can be used in bipolar |
|
|
Term
|
Definition
1. Extended release for of Risperidone's major metabolite! (an atypical antipsychotic)
2. atypical antipsychotics particularly helpful in bipolar! |
|
|
Term
|
Definition
1. 5-HT1 receptor agonist likely mediates thru vasoconstriction and sensory neuron presynaptic inhibition
2. acute migraine (not prophylaxis)
3. iono- and chrono-tropic heart effects, nausea, dizzy, weak, contra to vasoconstrictive problems, MAOIs |
|
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Term
|
Definition
1. agonist OR antag to 5-HT1-R.
2. tx for migraine due to the agonist effects
3. CNS actions of nausea, vasoconstriction, leg weakness, muscle pain; Contra to Pregnancy bc they can stimulate the uterus and constrict uterine blood flow; fibrosis with long term tx |
|
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Term
|
Definition
1. agonist OR antag to 5-HT1-R.
2. prophylaxis tx for migraine due to the ANTAGONIST effects
3. CNS actions of nausea, vasoconstriction, leg weakness, muscle pain; Contra to Pregnancy; fibrosis with long term tx |
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