Term
| What causes changes in the CNS as a result of Aging? |
|
Definition
| changes in DNA, RNA, proteins in the CNS |
|
|
Term
|
Definition
| decreased brain weight, secondary loss of brain tissue and atrophy |
|
|
Term
|
Definition
| decreased nerve conduction velocity in motor and sensory systems |
|
|
Term
|
Definition
| neuraonal changes, such as accumulation of lipofuscin |
|
|
Term
|
Definition
| pigmented lipid found in the cytoplasm of neurons |
|
|
Term
|
Definition
| formation of senile plaques in the cerebral cortex |
|
|
Term
| What do senile plaques contain? |
|
Definition
| degenerated axons, dendrites, astrocytes, amyloid |
|
|
Term
|
Definition
| increased concentration of neurofibrillary tangles leading to distortion of cell bodies |
|
|
Term
|
Definition
| reduction in blood supply |
|
|
Term
|
Definition
| changes in neurotransmitter activity |
|
|
Term
|
Definition
| impaired balance and mobility |
|
|
Term
| Why are balance and mobility affected with age? |
|
Definition
| degeneration of the vestibular system, declines in vision and somatosensory function |
|
|
Term
|
Definition
| increased susceptibility for neurologic disease |
|
|
Term
|
Definition
|
|
Term
| involves cellualr swelling, loss of cellular integrity, fragmentation, lysis |
|
Definition
|
|
Term
| toxins are released that have a destructive effect on neighboring cells |
|
Definition
|
|
Term
|
Definition
|
|
Term
| inflammation of the meningeal layer of the spinal cord or brain |
|
Definition
|
|
Term
| Inflammation as a result of meningitis may extend to where |
|
Definition
| dura, arachnoid, pia into the cortex of the brain and/or spinal cord |
|
|
Term
|
Definition
| injury to the meninges, inner ear infection |
|
|
Term
| Symptoms of meningitis: Initial |
|
Definition
| fever, headaches, stiff painful neck |
|
|
Term
| Kernig's Sign: As leg is flexed |
|
Definition
|
|
Term
| Brudzinskis sign: as head flexes |
|
Definition
|
|
Term
| Meninigitis: As symptoms progress |
|
Definition
| seizures, coma, vomiting, papilledema, cranial nerve dysfunction |
|
|
Term
|
Definition
| optic disc swelling caused by increased ICP |
|
|
Term
|
Definition
|
|
Term
| What is a primary CNS tumor? |
|
Definition
| develops in the brain, spinal cord, or surrounding structures |
|
|
Term
| What is a secondary CNS tumor? |
|
Definition
| tumors that metatasize to the location |
|
|
Term
| How do SOL affect nerve function |
|
Definition
| may lead to mild lethargy to paralysis |
|
|
Term
| How do priamry tumors affect the brain: 1 |
|
Definition
| compression of the cerebral tissue |
|
|
Term
| How do priamry tumors affect the brain: 2 |
|
Definition
| invasion or infiltration of the brain tissue |
|
|
Term
| How do priamry tumors affect the brain: 3 |
|
Definition
| erosion of the bone that protects the CNS |
|
|
Term
| Compression of the cerebral tissue, as well as invasion or infiltration of the bone tissue may lead to what |
|
Definition
| cerebral edema and a resultant increase in ICP |
|
|
Term
| Edema acummulation and tumor growth may also cause what |
|
Definition
| flow of CSF to be stopped |
|
|
Term
| Symptoms related to increased ICP: 1 |
|
Definition
|
|
Term
| Symptoms related to increased ICP: 2 |
|
Definition
|
|
Term
| Symptoms related to increased ICP: 3 |
|
Definition
|
|
Term
| Symptoms related to increased ICP: 4 |
|
Definition
|
|
Term
| Symptoms related to increased ICP: 5 |
|
Definition
|
|
Term
| Symptoms related to increased ICP: 6 |
|
Definition
|
|
Term
| What is the most common type of brain tumor |
|
Definition
|
|
Term
| A glioma may involve tumor growth where |
|
Definition
| astrocytes, oligodendrocytes, ependymal cells |
|
|
Term
| The tumors are slow growing and usually beningn |
|
Definition
|
|
Term
| Where do meningiomas grow? |
|
Definition
| dura mater, cerebral convexities |
|
|
Term
| Gliomas are thought to be a choromosmoal defect or absence of what |
|
Definition
|
|
Term
| Meningiomas are related to multiple deletions on chromosome |
|
Definition
|
|
Term
| Where does meningioma growth start |
|
Definition
| arachnoid layer of the meninges |
|
|
Term
| The meningioma then infiltrates what part |
|
Definition
|
|
Term
| Due to their proximity to the bony cranium, some meningiomas lead to increased what |
|
Definition
| bone growth, hyperostosis |
|
|
Term
| Clinical Picture Meningioma: |
|
Definition
| patient complains of mild symptoms that increase over years |
|
|
Term
| What is another name for a neurinoma |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Schwannomas tend to grow where |
|
Definition
| vestibular portion of CN8 |
|
|
Term
| Schwannoma of CN#8 has what sypmtoms |
|
Definition
| uniltaeral hearing loss, tinnitus, vertigo, unsteadiness |
|
|
Term
| As a CN8 tumor grows, what may be compressed |
|
Definition
|
|
Term
| Compression of CN7 may result in what |
|
Definition
| facial numbness, dyshapgia, facial muscle weakness |
|
|
Term
| Primary spinal cord tumors are ____ common than brain tumors |
|
Definition
|
|
Term
| Spinal tumors are the _____ found within the brain |
|
Definition
|
|
Term
| Which is the most prevalent spinal tumor |
|
Definition
|
|
Term
| Which is the second most prevalent tumor |
|
Definition
|
|
Term
| Which is the least prevalent spinal tumor |
|
Definition
|
|
Term
| How are spinal tumors named |
|
Definition
| by their location in the cord |
|
|
Term
| Intra-dural-intramedullary tumors grow where |
|
Definition
|
|
Term
| Intradural-intramedullary tumors are prevalent in which population |
|
Definition
|
|
Term
| Intradural-intramedullary tumors arise form where |
|
Definition
| cells within the cord such as astrocytes and ependymal cells |
|
|
Term
| Intradural-intramedullary cells tend to be |
|
Definition
|
|
Term
| Intradural-extramedullary tumors grow where |
|
Definition
| outside of the spinal cord but within the dura |
|
|
Term
| intradural-extramedullary tumors are most comon among who |
|
Definition
|
|
Term
| intradural-extramedullary tumors tend to arise from where |
|
Definition
| supporting tissue of teh CNS, ie meninges or nerve sheath |
|
|
Term
| How do intradural-extramedullary tumors grow |
|
Definition
|
|
Term
| Extradural-extramedullary tumors are typically |
|
Definition
|
|
Term
| Extradural-extramedullary tumors can develop from what |
|
Definition
| schwannoma or meningioma that grows extradurally |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
