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CNS Stimulants - Updated
Pharm Assessment 13
14
Pharmacology
Graduate
02/11/2012

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Cards

Term
What are the indirect dopamine agonists?
Definition
Amphetamine
Dextro-amphetamine
Methylphenidate
Term
What are the Indirect norepinephrine agonists?
Definition
Atomoxetine
Term
What are the Indirect serotonin agonist?
Definition
Phentermine
Term
What are the other CNS stimulants?
Definition
Sibutramine
Modafinil
Term
How is Dopamine affected by Amphetamine?
Definition
Releases dopamine in reward pathways
Term
What has been suggested to be caused by Amphetamines with pregnancy?
Definition
premature delivery
placental abruption
fetal growth retardation
heart and brain abnormalities
Term
What is Phentermine used to treat?
Definition
Obesity
Term
What drug is used to treat narcolepsy and has no effect on dopamine systems?
Definition
Modafinil

(Little or no abuse liability)
Term
What enzymes does Modafinil induce?
Definition
midrosomal enzymes

decreased levels of drugs metabolized by these enzymes
Term
What is the only drug specifically approved for adult ADHD?
Definition
Atomoxetine
Term
How does Atomoxetine work?
Definition
Norepinephrine Reuptake inhibitor
Term
What CNS stimulant blocks dopamine, norepinephrine and serotonin reuptake?
Definition
Sibutramine

(Removed from market)
Term
What are the concerns with Sibutramine?
Definition
Blood Pressure
Serotonin Syndrome
Abuse/Dependence
Term
What drug can be used to block euphoria caused by Cocaine?
Definition
Modafinil
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