Term
| Acute neuronal injury (red neuron) |
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Definition
| pyknosis of nucleus, loss of Nissl substance, acute CNS hypoxia/ischemia |
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Term
| Subacute & chronic neuronal injury ("degeneration") |
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Definition
| amyotrophic lateral sclerosis, Transsynaptic degeneration |
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Term
| Intracytoplasmic inclusions; Proteinopathies |
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Definition
| degenerative diseases of CNS |
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Term
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Definition
| abnormal vacuolization of perikaryon & neuronal cell processes in the neuropil |
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Term
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Definition
| Cowdry bodies (neuronal inclusions) |
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Term
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Definition
| most important histopathologic indicator of CNS injury, GFAP+ |
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Term
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Definition
| proliferation of astrocytes b/t molecular & granule cell layers of cerebellum b/c anoxic injury & death of Purkinje cells |
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Term
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Definition
| hick, elongated, brightly eosinophilic structures,cerebellar pilocytic astrocytoma,Alexander disease |
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Term
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Definition
| (leukodystrophy due to mutation in GFAP) -> Rosenthal fibers abundant in periventricular, perivascular, subpial |
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Term
| Corpora amylacea/ Polyglucosan bodies |
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Definition
| degerative change in the astrocyte, increased #'s w/ advancing age & in rare condition called adult polyglucosan body disease |
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Term
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Definition
| Lafora bodies (similiar structure & composition to Polyglucosan bodies) |
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