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CNS/NEURO Pathology
Path Buzz Words
11
Health Care
Graduate
04/15/2009

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Cards

Term
Acute neuronal injury (red neuron)
Definition
pyknosis of nucleus, loss of Nissl substance, acute CNS hypoxia/ischemia
Term
Subacute & chronic neuronal injury ("degeneration")
Definition
amyotrophic lateral sclerosis, Transsynaptic degeneration
Term
Intracytoplasmic inclusions; Proteinopathies
Definition
degenerative diseases of CNS
Term
Creutzfeldt-Jakob's
Definition
abnormal vacuolization of perikaryon & neuronal cell processes in the neuropil
Term
Herpes
Definition
Cowdry bodies (neuronal inclusions)
Term
Gliosis
Definition
most important histopathologic indicator of CNS injury, GFAP+
Term
Bergmann gliosis
Definition
proliferation of astrocytes b/t molecular & granule cell layers of cerebellum b/c anoxic injury & death of Purkinje cells
Term
Rosenthal fibers
Definition
hick, elongated, brightly eosinophilic structures,cerebellar pilocytic astrocytoma,Alexander disease
Term
Alexander disease
Definition
(leukodystrophy due to mutation in GFAP) -> Rosenthal fibers abundant in periventricular, perivascular, subpial
Term
Corpora amylacea/ Polyglucosan bodies
Definition
degerative change in the astrocyte, increased #'s w/ advancing age & in rare condition called adult polyglucosan body disease
Term
Myoclonic epilepsy
Definition
Lafora bodies (similiar structure & composition to Polyglucosan bodies)
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