Term
| Clinical Features of Depression |
|
Definition
|
|
Term
| Tricyclic Antidepressants |
|
Definition
-blocks reuptake of monoamine neurotransmitter --> norepinephrine/serotonin
-nucleus of this drug has 3 rings
-similar to typical antipsychotics |
|
|
Term
|
Definition
1. orthostatic hypotension
2. anticholinergic effects
3. sedation
4. Cardiac toxicity |
|
|
Term
|
Definition
Depression
Schizophrenia
Insomnia
Neuropathic pain
Withdrawal |
|
|
Term
|
Definition
1. MAOI - HTN
2. Antihistamines - anticholinergics
3. Direct sympahtomimetics ( increase intensity)
4. Indirect sympathomimetics ( decreased response of these meds)
5. ETOH, CNS depressants |
|
|
Term
| Selective Serotonin Reuptake Inhibitors (SSRI) |
|
Definition
fluoxetine (Prozac)
sertaline (Zoloft)
citalopram (Celexa)
escitalpram (Lexapro)
paraoxetine (Paxil) |
|
|
Term
|
Definition
-selective inhibition of serotinin reuptake
- allows more serotonin in postsynaptic
-results in increase serotinin and increase CNS excitation |
|
|
Term
|
Definition
-depression
-OCD
-bulima nervosa
-premenstrual dysphoric disorder
-PTSD |
|
|
Term
|
Definition
1. Weight gain
2. Sexual Dysfunction
3. Serotonin Syndrome ( mental confusion, agitation, anxiety)
4. Withdrawal symptoms
5. Bruxism
6. rare EPS
7. take at night (sleepyness)
8. hypOnatremia |
|
|
Term
| drug interactions of SSRI |
|
Definition
1. MAOI - serotonin syndrome
2. Warfarin - decrease warfarin
3. TCA & Lithium - avoid
4. NSAIDS/Anticoagulants - bleeding |
|
|
Term
|
Definition
Serotonin/Norepinephrine reuptake inhibior
-major depression
-GAD |
|
|
Term
| action of venlafaxine (Effexor) |
|
Definition
| blocks NE and serotonin reuptake |
|
|
Term
| T/F Serious reactions do not occur when Effexor is combined with MAOIs |
|
Definition
False
can cause serotonin syndrome |
|
|
Term
| Monoamine Oxidase Inhibitors |
|
Definition
converts NE, serotonin and DA into inactive products
-inactivates tyramine and other biogenic amines
--> neutral effect |
|
|
Term
|
Definition
Atypical depression
Belumia nervosa
OCD |
|
|
Term
|
Definition
1. CNS stimulation
2. Orthostatic hypotension
3. HTN crisis (from tyramine intake; TCA)
managed with phentolamine or nifedipine SL |
|
|
Term
| use MAOI cautiously in ___ & ____ |
|
Definition
|
|
Term
| drug interactions with MAOIs |
|
Definition
1. Ephedrine, amphetamine
(-promotes release of NE --> HTN crisis)
2. SSRI
3. Meperidine --> hyperexia
4. Vasopressors
5. Barbituates
6. CNS
7. AntiHTN |
|
|
Term
|
Definition
aged chees
hearring
broad beans
yeast |
|
|
Term
|
Definition
bupropion (Wellbutrin)
mirtazapine (Remeron)
venlafaxine (Effexor)
reoxetine (Vestra)
trazodone (Desyrel) |
|
|
Term
| action of atypical antidepressants |
|
Definition
-inhibits dopamine uptake
-does NOT affect serotonergic, cholinergic, or histaminergic transmission |
|
|
Term
| uses for Atypical Antidepressants |
|
Definition
1. Treatment for depression
2. Acts a stimulant and suppresses appetite
3. Aid to quit smoking |
|
|
Term
| T/F atypical antidepressant effects begins in 1-3 weeks |
|
Definition
|
|
Term
| T/F Atypical antidepressants (Wellburtrin) decreases sexual function/pleasure |
|
Definition
|
|
Term
| T/F wellbutrtin and other atypical antidepressants should be given at night. |
|
Definition
False
-in the morning b/c can cause insomnia |
|
|
Term
| s/e of atypical antidepressants |
|
Definition
1. Seizures
2. Agitiation
3. Tremors
4. Tachycardia, blurred vision
5. Insomnia |
|
|
Term
| atypical antidepressants are NOT for |
|
Definition
1. seizures
2. CAD
3. DM
4. hyperthyroidism
5. Urinary retention/obstruction |
|
|
