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CNS Medications
Antidepressants
27
Pharmacology
Undergraduate 2
05/18/2011

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Cards

Term
Clinical Features of Depression
Definition
SIG E CAPS
Term
Tricyclic Antidepressants
Definition
-blocks reuptake of monoamine neurotransmitter --> norepinephrine/serotonin
-nucleus of this drug has 3 rings
-similar to typical antipsychotics
Term
s/e of TCA
Definition
1. orthostatic hypotension
2. anticholinergic effects
3. sedation
4. Cardiac toxicity
Term
uses for TCA
Definition
Depression
Schizophrenia
Insomnia
Neuropathic pain
Withdrawal
Term
drug interactions of TCA
Definition
1. MAOI - HTN
2. Antihistamines - anticholinergics
3. Direct sympahtomimetics ( increase intensity)
4. Indirect sympathomimetics ( decreased response of these meds)
5. ETOH, CNS depressants
Term
Selective Serotonin Reuptake Inhibitors (SSRI)
Definition
fluoxetine (Prozac)
sertaline (Zoloft)
citalopram (Celexa)
escitalpram (Lexapro)
paraoxetine (Paxil)
Term
Action of SSRI
Definition
-selective inhibition of serotinin reuptake
- allows more serotonin in postsynaptic
-results in increase serotinin and increase CNS excitation
Term
uses for SSRI
Definition
-depression
-OCD
-bulima nervosa
-premenstrual dysphoric disorder
-PTSD
Term
s/e of SSRI
Definition
1. Weight gain
2. Sexual Dysfunction
3. Serotonin Syndrome ( mental confusion, agitation, anxiety)
4. Withdrawal symptoms
5. Bruxism
6. rare EPS
7. take at night (sleepyness)
8. hypOnatremia
Term
drug interactions of SSRI
Definition
1. MAOI - serotonin syndrome
2. Warfarin - decrease warfarin
3. TCA & Lithium - avoid
4. NSAIDS/Anticoagulants - bleeding
Term
Venlafaxine (Effexor)
Definition
Serotonin/Norepinephrine reuptake inhibior
-major depression
-GAD
Term
action of venlafaxine (Effexor)
Definition
blocks NE and serotonin reuptake
Term
T/F Serious reactions do not occur when Effexor is combined with MAOIs
Definition
False
can cause serotonin syndrome
Term
Monoamine Oxidase Inhibitors
Definition
converts NE, serotonin and DA into inactive products
-inactivates tyramine and other biogenic amines
--> neutral effect
Term
uses for MAOIs
Definition
Atypical depression
Belumia nervosa
OCD
Term
s/e of MAOIs
Definition
1. CNS stimulation
2. Orthostatic hypotension
3. HTN crisis (from tyramine intake; TCA)
managed with phentolamine or nifedipine SL
Term
use MAOI cautiously in ___ & ____
Definition
DM and seizures
Term
drug interactions with MAOIs
Definition
1. Ephedrine, amphetamine
(-promotes release of NE --> HTN crisis)
2. SSRI
3. Meperidine --> hyperexia
4. Vasopressors
5. Barbituates
6. CNS
7. AntiHTN
Term
foods to avoid with MAOI
Definition
aged chees
hearring
broad beans
yeast
Term
atypical antidepressants
Definition
bupropion (Wellbutrin)
mirtazapine (Remeron)
venlafaxine (Effexor)
reoxetine (Vestra)
trazodone (Desyrel)
Term
action of atypical antidepressants
Definition
-inhibits dopamine uptake
-does NOT affect serotonergic, cholinergic, or histaminergic transmission
Term
uses for Atypical Antidepressants
Definition
1. Treatment for depression
2. Acts a stimulant and suppresses appetite
3. Aid to quit smoking
Term
T/F atypical antidepressant effects begins in 1-3 weeks
Definition
true
Term
T/F Atypical antidepressants (Wellburtrin) decreases sexual function/pleasure
Definition
false - increase
Term
T/F wellbutrtin and other atypical antidepressants should be given at night.
Definition
False
-in the morning b/c can cause insomnia
Term
s/e of atypical antidepressants
Definition
1. Seizures
2. Agitiation
3. Tremors
4. Tachycardia, blurred vision
5. Insomnia
Term
atypical antidepressants are NOT for
Definition
1. seizures
2. CAD
3. DM
4. hyperthyroidism
5. Urinary retention/obstruction
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