Term
Antispychotic Agents and Schizophrenia
Typical |
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Definition
1. Typical-
low potency= Thorazine (chlorpromazine)
high potency = Haldol (haloperidol) |
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Term
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Definition
-act to block post synaptic dopamine receptors in the brain
-this allows typical antipsychotics to have a greater affinity to D2 receptors |
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Term
| Antipsychotics (Atypical) |
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Definition
2. Atypical
-risperidone
-clozapine
-olanzapine
-quetapine
-ariprazole (abilify) |
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Term
| action of typical antipyschotics |
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Definition
| dopamine, acetycholine, histamine, ne receotrs in brain are BLOCKEd --> increase DA availability |
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Term
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Definition
1. schizophrenia
2. bipolar disorder
3. Huntington's
4. Dementia
5. Tourettes syndrome
6. Delusional disorders |
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Term
s/e of typical antidepressants
early EPS |
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Definition
1. Early EPS
akathsia
dystonia
drug induced parkinsonism
Tx:
-benztropine/diphenydramine
-switch to risperidone (atypical) |
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Term
s/e of typical antidepressants
late EPS |
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Definition
1. Tardive dyskinesia
--> evaulat after 12 months, switch to risperidone |
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Term
| Typical Antipyschotlc s/e |
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Definition
1. Early/late EPS
2. Neuroleptic malignia
3. Anticholinergic effects
4. Bone marrow suppression
5. CV
6. Hepatoxicity
7. |
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Term
| Atypical Antipsychotic S/e |
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Definition
1. Endocrine changes
-sexual (gycomastia, impotence)
-breast enlargement --> increase prolactin levels --> increase risk of breast cancer
-weight gain
-hyperglycemia
3. Liver toxicity
4. Ocular toxicity
5. Seizures
6. Allergy skin reactions |
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Term
| Interactions of antipsychotics |
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Definition
1. Avoid anticholinergics
2. CNS depressants
3. Levodopa (counteracts effects of antipsychotic agents) |
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Term
| Action of Atypical Antipsychotics |
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Definition
| -blocks SE and to a lesser degree - dopamine, ne, ach, histamine |
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