Term
Clozapine
Start with 12.5 QD or BOD
inc by 25mg every other day
until 150-225 BID
(max dose 900/day) |
|
Definition
Side effects:
sedation
drooling
tremor
tachycardia (beware mmyocarditis)
hypotension
constipation
blurred vision
SEIZURES!
(LOWERS SZ THRESHOLD)
AGRANULOCYTOSIS!!!
benign fever
weight gain
metabolic synrome |
|
|
Term
stop clozapine if
WBC less than 3000
or
ANC less than 1500
(do not rechallenge if and under 1000) |
|
Definition
get physical exam
&
CBC
(and other labs you would do for atypicals) |
|
|
Term
hold for low BP (90/50) or high 160/110?
hold for high or low pulse (60...120)
hold for fever over 101 & evluate |
|
Definition
| prozac, paxil (a little) & luvox!! may elevate levels? |
|
|
Term
| at 300mg a day wait 5 days & draw level |
|
Definition
weekly CBC for 6 months
then every other week |
|
|
Term
| watch out for myoclonic jerks - get EEG! |
|
Definition
myocarditis:
fatigue, SOB, tachypnea, feer, chest pain, palpitations,
OKG may show ST wave abnormailities or arhythmias |
|
|
Term
Don't use with
Tegretol (Carbamazepine) !
( which surpresses bone marrow) |
|
Definition
with benzo - be careful
report of cirulatory collapse |
|
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