Term
| 7 yo girl w/ fever, swollen erythematous knee. Joint fluid is cloudy w/ gm + bacteria and many PMN. What is most likey diagnosis? |
|
Definition
|
|
Term
14yo bone bain, swelling, tenderness in right distal femur.
Decreased range of motion, X-ray w/ elevation of periosteum and sunburst pattern. What is most likely diagnosis? |
|
Definition
|
|
Term
| 7yo w/ leg pain. Bone w/ onion skinning. BIopsy w/ sheets of small uniform round cells. |
|
Definition
|
|
Term
| 55yo w/ hx of osteoarthritis presents with swelling and pain in the midline of the posterior knee |
|
Definition
|
|
Term
| 32 yo woman w/ morning stiffness for >1 hour, pain in joints bilaterally, with fatigue and hand deformations. |
|
Definition
|
|
Term
| A patient with urethritis, conjunctivitis, arthritis, and HLA-B27 + |
|
Definition
|
|
Term
| 43 yo w/ hx of falling on knee 2 days ago. Knee is red, swollen, and warm |
|
Definition
|
|
Term
| 65 yo w/ 2 hr Hx of sudden onset of extreme pain in great toe |
|
Definition
|
|
Term
| 22 yo male w/ avascular necrosis of femoral head. Which hematologic disease should be considered? |
|
Definition
|
|
Term
| A 33 yo w/ joint main. His urine has increased in pigmentation and frequency and he tends to set off metal detectors.. |
|
Definition
|
|
Term
| 18 yo male w/ migratory arthritis, currently in ankle, a rash, pain w/ urination. Gm- urethral discharge |
|
Definition
|
|
Term
| 20 yo w/ 1 mos. hx of worsening back pain that is worse in the morning and improves with exercise |
|
Definition
|
|
Term
|
Definition
decrease production of inlammatory mediators, suppression of neutrophil migration. DMARD
SE:Acne, insomnia, edema, htn, osteoporosis, cataracts, glaucoma, psychosis, increased appetite, hirsutism, hyperglycemia, muscle wasting, pancreatitis, striae, redist. of body fat to abdomen, back and face |
|
|
Term
|
Definition
Recombinant tumor necrosis Factor (TNF) receptor linked to the Fc portion of human IgG; binds TNF and inhibits its interaction with cell surface receptors
DMARD
SE: hypersensitivity, headache, local inj. site reactions, respiratory tract infection, + ANA, activation of latent TB |
|
|
Term
|
Definition
Chimeric monoclonal antibody that binds to human TNF alpha thereby interfering with its activity
DMARD
SE:Headache, rach, nausea, diarrhea, UTI, inf. reactions, arthralgia, URI, act. of latent TB |
|
|
Term
|
Definition
Inhibits DHFR, increases adenosine levels (antiinflammatory) This is the most common treatment
DMARD
SE:Mucositis, nausea, vomiting, diarrhea, nephrotoxicity, leukopenia, thrombocytopenia, hepatoxicity, pneumoniitis, crystalluria |
|
|
Term
|
Definition
Interferes with lysosomal function; inhibits chemotaxis of neutrophils and eosinophils
DMARD
SE: CARDIOmyopathy, alopecia, visual disturbances, anorexia, nausea, vomiting, diarrhea, aplastic anemaia, agranulocytosis, hemolysis in G6PD def. Cinchonism, exacerbation of porphyria |
|
|
Term
|
Definition
inhibits phagocytosis and lysosomal enzyme activity of macrophages
DMARD
SE: Nephrotoxicity, dermatitis, alopecia, eosinophilia, leukopenia, thrombocytopenia, hematuria, nausea, vomiting |
|
|
Term
|
Definition
| Helps with RA somehow, but only in path stuff, not in pharm, |
|
|
Term
|
Definition
inhibits Xanthine oxidase
SE:skin rash mc, nausea, vomiting, renal impairment, ATN, agranulocytosis, SJS
Not used in acute gout attack b/c may prec. acute gouty arthritis, and therefore perpetuate the acute gout attack. (Prevention and NOT treatment) |
|
|
Term
| 3 uricosuric agents (enhancing renal excretion of uric acid) |
|
Definition
1)probenecid (inhibits proximal tubular resorption of uric acid)
2)sulfinpyrazone
3) High dose Aspirin |
|
|
Term
|
Definition
Colchicine (inhibits depoly. of MT, decreases leukocyte motility, decreases phagocytosis in joints and lactic acid prod, which decreases dep of urate crystals.
SE:Nausea, vomiting, diarrhea, abdominal pain, agranulosytosis, aplastic anemia, BM suppression, alopecia, myopathy, arrhytmia, hepatotoxicity
; NSAIDS |
|
|
