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Clinical Use Sedative AntiAnx
Clinical Uses of Sedative/Antianxiety Drugs
33
Biology
Graduate
11/28/2008

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Term
Patient preparation
NPO standards
Definition
No solid food or milk for 6-8 hr
Clear liquids up to 2 hr before treatment
Term
Postoperative instructions
Definition
Ambulatory status
Driving status
Use of other drugs
Food intake
Term
Individual Benzodiazepines
3
Definition
Diazepam
Lorazepam
Triazolam
Term
Diazepam (Valium)
primary therapuetic uses
Definition
anxiety disorders, acute alcohol withdrawal, muscle relaxant, preoperative sedation, recurrent seizures
Term
Diazepam (Valium)Adverse effects:
Definition
CNS depression
Term
Diazepam (Valium) Precautions
Definition
myasthenia gravis, pulmonary disease, narrow-angle glaucoma, C-IV controlled substance, pregnancy category D 4 seizures
Term
Diazepam Dosage forms:
Definition
injection: 5 mg/mL in 1, 2, and 10 mg vials, 2 mL amps, and 2 mL syringes; tablets: 2, 5, and 10 mg; capsules (sustained release): 15 mg; solution: 5 mg/mL and 5 mg/5 mL
Term
Diazepam Directions
Definition
10 (2-15) mg 30 min before bedtime or 1 hr before treatment
Term
Diazepam Clinical duration
Definition
3hr, long half life
Term
Diazepam Recommendation
Definition
use with history of previous success
Term
Lorazepam (Ativan)
Primary therapeutic uses
Definition
anxiety disorders, preoperative sedation
Term
Lorazepam (Ativan)
Adverse effects 2
Definition
CNS depression, amnesia memory
Term
Lorazepam (Ativan)Precautions
\pregancy category
Definition
myasthenia gravis, pulmonary disease, narrow-angle glaucoma, C-IV controlled substance, pregnancy category D
Term
Lorazepam Dosage forms
Definition
Dosage forms: injection: 2 and 4 mg/mL in 1 and 10 mL vials and 1 mL Tubex; tablets: 0.5 , 1, and 2 mg
Term
Lorazepam Directions
Definition
2 (1-4) mg 1 hr before bedtime or 2 hr before treatment
Term
Lorazepam Clinical duration
Definition
6 hr slower onset, long procedures
Term
Lorazepam Recommendation
Definition
Recommendation: use for prolonged procedures or when treatment is delayed
Term
Triazolam (Halcion)Primary therapeutic uses:
Definition
insomnia
Term
Triazolam (Halcion) Adverse effects:
Definition
CNS depression, amnesia
Term
Triazolam (Halcion)Precautions
Definition
myasthenia gravis, pulmonary disease, narrow-angle glaucoma, C-IV controlled substance, pregnancy category X
Term
Triazolam (Halcion)

Dosage forms: sometimes give_____
Directions:
Clinical duration:
Recommendation:
Definition
Dosage forms: tablets: 0.125 and 0.25 sublingually
Directions: 0.25 (0.125-0.5) mg 30 min before bedtime or 45 min before treatment
Clinical duration: 2 hr
Recommendation: use for insomnia and short cases
Term
Selective w1 agonists)
Definition
Zolpidem
Term
Zolpidem Tartrate (Ambien)
primary therpeutic use
adverse effects
precasutions
dosage forms
Definition
Primary therapeutic use: insomnia
Adverse effects: CNS depression
Precautions: hepatic function impairment, new drug (pregnancy category B)
Dosage forms: tablets: 5 and 10 mg
Term
vZolpidem (Ambien) direction duration reccommendation
Definition
Directions: 10 (5-20) mg immediately before bedtime or 20 min before treatment
Clinical duration: 2 hr
Recommendation: use when rapid effect is desired
of choice for pregnancy
Term
Alcohols
Definition
Chloral hydrate
Ethanol
Term
Chloral hydrate
tx use
adverse
preacutions
Definition
Primary therapeutic uses: insomnia, preoperative sedation, acute alcohol withdrawal
Adverse effects: CNS depression, mucosal irritation, nausea and vomiting, sensitize heart to epi
Precautions: GI ulceration; certain porphyrias, C-IV controlled substance, oral anticoagulants
Term
Chloral hydrate for kids
Definition
lousy
Term
Chloral hydrate duratoin, reccomandation
Definition
Clinical duration: 3 hr
Recommendation: use safer agents as lethal blood concentrations encompass the therapeutic range
Term
ethanol
tx use
advers
precautions
Definition
Primary therapeutic uses: methanol intoxication, drug vehicle, rubefacient, antiseptic, nerve destruction
Adverse effects: CNS depression, mucosal irritation, nausea and vomiting
Precautions: GI ulceration
Term
ethanol
dosage...
directions...
duration....
recommednation...
Definition
Dosage forms: various
Directions: 1-2 glasses of wine 15 min before treatment
Clinical duration: 45 min
Recommendation: may use in patients aversive to “drugs”
Term
Hydroxyzine
Definition
Antihistamine
Modest antianxiety effect at low doses
Low toxicity used alone
Term
Hydroxyzine (Atarax, Vistaril)
tx uses
adverse
precautions
directions
duration
Recommendation
Definition
Primary therapeutic uses: anxiety disorders, preoperative sedation, allergic reactions, acute alcohol withdrawal, opioid adjunct
Adverse effects: CNS depression (mild), antimuscarinic effects (weak)
Precautions: pregnancy, use IM route only for injection
1hr before tx
4hr
Recommendation: may use in patients with previous success or for antiemetic/antihistaminic properties
Term
state law
certificate required if
Definition
Special oral sedation certificate is required if:
Used in children under 13 yr
Used in adults beyond MRD
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