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Clinical use of stimulants
ADHD and Obesity
13
Medical
Graduate
04/10/2010

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Cards

Term
First line against ADHD
Definition
Methylphenidate or amphetamine are most effective. These are psychostimulants that act via increasing DA and NE in synapses. Slow action hence not so addictive.
Term
Atomoxetine
Definition
Not as efficaciousas mehtylphenidate or amphetamine, but also used in treatment of ADHD. (inhibits NE reuptake)
Term
Alternatives to stimulants for ADHD
Definition
TCAs (inhibits NE and 5HT reuptake), Clonidine & guanfecine (alpha 2 agonists, sedating), Bupropion (inhibits DA reuptake; increases tics and seizures)
Term
Basis of stimulant action in ADHD
Definition
increase DA and/or NE in synapses. DA and NE are involved in attention mechanisms.
Term
How do CB1 receptor antagonists affect weight?
Definition
Decrease weight.
Term
CB1 agonists like THC (marijuana) increase/ decrease weight?
Definition
increase
Term
Benzphetamine (Didrex)
Definition
NE, DA releasing anorectic drug for obesity
Term
phendimetrazine (Adipos)
Definition
NE, DA releasing anorectic drug for obesity
Term
Phentermine (Adipex)
Definition
NE, DA releasing anorectic drug for obesity
Term
Diethylpropion (Tenuate)
Definition
NE, DA releasing anorectic drug for obesity
Term
Sibutramine (Meridia)
Definition
NE, 5HT releasing anorectic drug for obesity
Term
Drugs that increase NE and 5HT are used for controls of eating because
Definition
NE inhibits hunger signal; 5HT activates satiety signal.
Term
D2 antagonists are first gen antipsychotic agents. They also supress or increase the vomiting reflex?
Definition
Suppress vomiting reflex.
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