Term
| Muscle relaxers are used for |
|
Definition
1. Diminish Skeletal muscle
ex. Muscle strain
2. Reduce spasticity & hyperreflexia
ex. SC injury, cerebral palsy
3. Tetanus |
|
|
Term
| Spasticity is an increase to ______ movements |
|
Definition
|
|
Term
| Name the Centrally acting muscle relaxants |
|
Definition
1. Mephenesin
2. Cyclobenzaprine
3. Diazepam
4. Baclofen
5. Tizainidine |
|
|
Term
| Mephenesin is thought to act on the _______ _______ in the brain stem |
|
Definition
|
|
Term
| name an adverse effect of Mephenesin |
|
Definition
|
|
Term
| Mephenesin causes muscle relaxation by what method? |
|
Definition
| Reduces input from the reticular formation onto the Motor neurons in the spinal cord |
|
|
Term
| What's the MOA for Cyclobenaprine |
|
Definition
|
|
Term
| Name the two adverse effects of cyclobenzaprine |
|
Definition
| Sedation and Anti-Muscarinic effects |
|
|
Term
|
Definition
|
|
Term
| What's the MOA of Diazepam |
|
Definition
|
|
Term
| Give the Side effect of Diazepam |
|
Definition
|
|
Term
| Besides muscle relaxation, what are the other uses for Diazepam |
|
Definition
Sedataive-hypnotic
Anti-anxiety
Anti-epileptic |
|
|
Term
| Baclofen is a ______ agonist |
|
Definition
|
|
Term
| How does baclofen cause muscle relaxation |
|
Definition
| Decreases the release of excitatory NT via pre-synaptic inhibition |
|
|
Term
| A side effect of Baclofen is ____ but less than the Benzodiazepine |
|
Definition
|
|
Term
| An adverse effect of Baclofen is less ______ weakness than dantrolene |
|
Definition
|
|
Term
| Tizainidine is a ______ acting Alpha _______ agonist |
|
Definition
| short acting alpha adrenergic agonist |
|
|
Term
| Tizainidine causes muscle relaxation by |
|
Definition
| increasing presynaptic inhibition at the level of the motor neuron |
|
|
Term
| What are the adverse effects of Tizainidine |
|
Definition
Decrease muscle tone
Decrease muscle spasticity |
|
|
Term
| Name the Non-centrally acting muscle relaxants |
|
Definition
|
|
Term
| What are the MOA for Dantrolene |
|
Definition
Act on skeletal muscle contractile mechanism
Decrease calcium release from SR
Fast fibers more sensitive |
|
|
Term
| What's a major side effect of Dantrolene |
|
Definition
|
|
Term
| Other than muscle relaxation, what other uses are there for Dantrolene |
|
Definition
Maligant Hyperthermia spasm
Severe muscle contractoin |
|
|
Term
| Non depolarizing neuromuscular blocking agents work by |
|
Definition
| blocking cholinergic nicotinic receptors and causing paralysis |
|
|
Term
| non depolarizing neuromuscular blocking agents can be reversed by |
|
Definition
|
|
Term
| Name the 4 non depolarizing neuromuscular blocking agents |
|
Definition
D-tubocurarine
Pancuronium
Rocuronium
Succinylcholine |
|
|
Term
| Which of the non depolarizing neuromuscular blocking agents are long acting? intermediat acting and short acting? |
|
Definition
D-tubocurarine and Pancuronium are both long acting
rocuronium is intermediate
Succinylcholine is short acting |
|
|
Term
| What receptors does Succinylcholine act on? Is it an agonist or antagonist |
|
Definition
| Nicotinic receptors agonist |
|
|
Term
| How does Succinylcholine work? |
|
Definition
| It causes fasiculations followed by muscle paralysis |
|
|
Term
| What is a side effect of succinylcholine |
|
Definition
|
|
Term
| What are the uses for succinylcholine? |
|
Definition
Surgerical relaxation
Control of ventilation
Treatment of convulsions |
|
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