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Clinical lab
lecture 1
58
Other
Graduate
09/08/2009

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Term
plasma
Definition
clear, yellowish fluid
Term
constitutes more than half of blood's volume and consists mostly of water containing dissolved salts (electrolytes) and proteins
Definition
plasma
Term
makes plasma appear milky
Definition
after a very fatty meal or hyperlipidemia
Term
albumin
Definition
the major protein in plasma
Term
function of albumin
Definition
keeps fluid from leaking out of blood vessels and into tissues
Term
hormones and certain drugs
Definition
albumin binds to and carries these substances
Term
RBC
Definition
component of blood that transports oxygen with the hemoglobin molecule
Term
RBC shape
Definition
doubly concave, enucleated cells
Term
WBC are also known as
Definition
leukocytes
Term
normal WBC count
Definition
4-10,000 per micro liter
average is 7,000
Term
what function do WBCs play in the body?
Definition
circulate in the blood so they can be transported to the infected area
Term
5 main types of WBCs
Definition
neutrophils, eosinophils, basophils, lymphocytes, monocytes
Term
neutrophils
Definition
the body's main defense against bacteria
Term
neutrophils kill bacteria by this process..
Definition
phagocytosis
Term
how many bacteria can neutrophils phagocytize
Definition
5-20 bacteria in their lifetime
Term
describe the nucleus in neutrophils
Definition
multi-lobed, segmented or polymorphonuclear nucleus
(PMNs, polys, segs)
Term
bands
Definition
immature neutrophils that are seen in the blood
Term
when is there an increase in neutrophils and bands?
Definition
when a bacterial infection is present
Term
eosinophils
Definition
granulocytes that kill parasites
Term
eosinophils
Definition
have a role in allergic reactions
Term
basophils
Definition
not well understood, but function in allergic reactions
Term
basophils
Definition
release histamine and heparin
Term
histamine
Definition
causes blood vessels to leak and attract WBCs
Term
heparin
Definition
prevents clotting in the affected area so that WBCs can reach the bacteria
Term
what does a basophil look like under the microscope?
Definition
large, irregular shaped nucleus and coarse dark violet granules in the cytoplasm
Term
what are the 3 types of lymphocytes?
Definition
T lymphocytes, natural killer cells, and B lymphocytes
Term
T lymphocytes and natural killer cells
Definition
help protect against viral infections and can detect and destroy cancer cells
Term
B lymphocytes
Definition
develop into cells that produce antibodies
Term
monocytes
Definition
become larger and turn into macrophages in the tissue
Term
monocytes
Definition
phagocytize bacteria in the tissue throughout the body
Term
up to 100 in their lifetime
Definition
how many bacteria do monocytes phagocytize in the body?
Term
monocytes
Definition
destroy old, damaged, and dead cells in the body
Term
where are monocytes located in the body?
Definition
liver, spleen, lungs, lymph nodes, skin and intestine
Term
reticuloendothelial system
Definition
the system of macrophages scattered throughout the body
Term
platelets
Definition
formed in the bone marrow from megakaryocytes
Term
megakaryocytes
Definition
break up into fragments formint platelets
Term
platelets
Definition
do not have a nucleus and do not reproduce
Term
average of 10 days
Definition
how long to platelets live?
Term
platelet plug
Definition
platelets (thrombocytes)help blood to clot by forming a ....
Term
CBC (complete blood count)
Definition
the standard test for evaluation of blood cells
Term
hemaglobin, hematocrit, RBC count,RBC indices, WBC count, WBC differential, platelet count
Definition
battery of tests other than the CBS include...
Term
hemoglobin
Definition
concentration of Hb in the whole blood
Term
hematocrit
Definition
percent of whole blood comprised of RBCs
Term
anemia
Definition
if hematocrit or hemoglobin is low, this is indicated
Term
14-18 g/dL
Definition
hemoglobin range for males
Term
12-16g/dL
Definition
hemoglobin range for females
Term
hematocrit
Definition
hemoglobin x 3=_____
Term
African-Americans
Definition
this ethnic group can be 1-2% lower Hb than caucasions
Term
higher
Definition
the higher the altitude, the (higher/lower) the Hb count
Term
1 g/dL
Definition
Hb rises ___g/dL for each 3-4% decrease in O2 saturation.
Term
position, stress, smoking (slide 30)
Definition
what are some other considerations with regards to Hb?
Term
Mean Corpuscular Volume (MCV)
Definition
measure of the size or volume of the average RBC
Term
microcytic, normocytic, marcocytic
Definition
3 classes of MVC (mean corpuscular volume) anemia
Term
microcytic
Definition
decrease in RBC volume (<80fL)
Term
normocytic
Definition
normal RBC volume (80-96fL)
Term
macrocytic
Definition
elevation in RBC volume (>96 fL)
Term
mean corpuscular hemoglobin (MCH)
Definition
weight of Hb in the average cell
Term
mean corpuscular hemoglobin concentration (MCHC)
Definition
the amount of hemoglobin in the average RBC when compared to its size
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