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Clinical Disorders: Blood
Blood Disorders
11
Histology
Professional
08/24/2011

Additional Histology Flashcards

 


 

Cards

Term
Anisocytosis
Definition
RBCs are unequal sizes
Term
Poikilocytosis
Definition
Presence of 10%+ tear-drop shaped RBCs (Poikilocytes) in blood
Term
Anemia
Definition
Not enough erythrocytes/Hb
Term
Sickle Cell Anemia (SCA)
Definition
Glutamic Acid replaced by Valine in AA chain of Hemoglobin: gives RBC "sickle" shape and don't last long (thus anemia - not enough healthy RBCs)
Term
Thalassemia
Definition
Excess alpha or beta globins to compensate for deficiency of the other in the Hb: doesn't form tetramer and binds to RBC cell membrane and damages it
Term
Hereditary Spherocytosis
Definition
Defect in RBC memb proteins: RBC is sphere shaped rather than donut shaped
Term
Hemolytic Disease of the Newborn
Definition
Rh- mom passes Rh Ab to second Rh+ baby
Large amounts of bilirubin building in baby from breakdown of RBC and deposited on brain of newborn.
Term
Significance of HbA1c
Definition
HbA1c binds irreversibly to glucose so glucose levels are indicative for life of RBC (120 days): test for diabetes can be done at any time irrelevant to food consumption
Term
Hemophilia
Definition
Inherited deficiency of clotting factors for males: VIII (most common) and IX; males and females: Hemophilia C
Term
Acute Leukemia
Definition
Uncontrolled production of immature leukocytes (blasts): crowding out of red bone marrow prevents production of RBC and platelets
Classified myeloid (monocytes) or lymphoid (lymphocytes)
Term
Chronic Leukemia
Definition
Accumulation of mature WBC in bloodstream (do not die)
Classified myeloid (monocytes) or lymphoid (lymphocytes)
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