Term
| What is the Ref Range for CK-Creatine Kinase? |
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Definition
Males: 46-180mg/dl
Females: 15-171 mg/dL |
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Term
| What is the clinical signifance of CK |
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Definition
| Increases in brain, cardiac, muscle destruction |
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Term
| What are some examples of increases in CK? |
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Definition
Heart attack
Chronic heart failure
Muscular dystrophy
Epilepsey
Stroke
Tumors |
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Term
| What are the isoenzymes of CK |
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Definition
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Term
|
Definition
Skeletal/cardiac muscle
major in serum |
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Term
|
Definition
found in Heart muscle and skeletal muscles
help diagnoise MI |
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Term
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Definition
travels farthest
Brain
CNS-stroke |
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Term
| WHat is the clinical signifiance of LD-Lactate dehydrogenase? |
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Definition
Increases in heart, blood diseases
liver disease (hepatitis)
muscular dystrophy
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Term
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Definition
Tetramer 2H 2M
HHHH
HHHM
HHMM
HMMM
MMMM
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Term
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Definition
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Term
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Definition
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Term
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Definition
Spleen
Lungs
Many tissues
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Term
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Definition
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Term
| What are the ezymes in cardiac diseases? |
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Definition
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Term
| Increase in CK is due to? |
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Definition
MI
peaks @ 24hr
returns to normal in 2-4 days |
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Term
| Negative CK-MB indicates? |
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Definition
| 6-8hrs 95% nedgative predicative vaule indicates no MI |
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Term
| Main location of AST-Aspartate aminotransferase |
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Definition
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Term
| What are the clinical signifiance of AST? |
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Definition
Increases:
Liver
Heart
Muscles diseases
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Term
| Main location of ALT-Alanine aminotransferase |
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Definition
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Term
Highest elevation in ALT
more specific than AST |
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Definition
1. Acute viral hepatitis
2. Toxic hepatitis
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Term
| ALT decreases with patients with |
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Definition
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Term
| Location of ALP- Alkaline Phosphastase |
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Definition
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Term
| Clinical Signifance of ALP |
|
Definition
Help Diagnoise Liver and Bone disorders
Increased ALP in hepatobillary disease/ obstructions and bone diseases |
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Term
| Location of GGT-Gamma Glutamyl Tranferase |
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Definition
Serum
present in all cells except muscle, biliray and liver |
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Term
| Clinical signifance of GGT |
|
Definition
Increases in hepatobiliary disease
Helps differeniate between liver and bone diseases
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Term
Location of 5'-NT, 5'-nucleotidase?
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|
Definition
| VAriety fo tissues, specifically liver |
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Term
| Clinical Signifance of 5'-NT |
|
Definition
Elevated in biliary tract diseases
5'-NT with GGT and ALP determinei if ALP elvation is from bone of liver disease
ALP, GGT elevated = bone source of ALP |
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Term
|
Definition
Digestive
Salivary glands
acinar cells of pancreas |
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Term
| Clinical Significance of AMY |
|
Definition
increses in acute pancreatitis, obstructive liver disease and acute acholism
Associated with mumps, parotitis and lesions |
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Term
|
Definition
Digestive
acinar cells of pancreas |
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Term
| Clinical Signifance of Lipase |
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Definition
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Term
| Clinical Signifance of TRY-Trypsin |
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Definition
| Screening for cystic fibrosis, chronic pancreatitis |
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Term
| Clinical Signifance of CHY-Chymotrypsin |
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Definition
| Investiagete chronic pancreatitis |
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Term
| Location of Acid Phospahte-ACP |
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Definition
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Term
| Clinical Signficance of ALP |
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Definition
| Screening for prosate cancer --> PSA |
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Term
| Clinical SIgnifance of ALD-Aldolase |
|
Definition
Helpful in diagnosing/montoring sketelal muscle diseases
Increases in ALD with CK:AST ratio help to differentaite neuro musclaular disease |
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Term
| What are the 2 groups of CHE- Cholinesterase |
|
Definition
ACHE
pseudocholinesterrase |
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Term
|
Definition
red cells
lungs
spleen
CNS-gray matter nerver endings |
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Term
|
Definition
| transmission of nerve impulses |
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Term
| Location of pseudocholinesterase? |
|
Definition
serum
liver
white matter of brain |
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Term
| CS of pseudocholinesterase |
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Definition
test liver fxn
dectect pesticide poisoning
detection of abnormal genetic variants |
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Term
|
Definition
Increase in all ezymes EXCEPT for ALD, and 5'-NT
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Term
|
Definition
| Increaese in all except for AST and ALP |
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Term
|
Definition
Catalyze oxidation reduction rxn
LD |
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Term
|
Definition
Catalyze transfer a group other than Hydrogen
AST |
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Term
|
Definition
Catalyze hydrolytic (cleavage of compounds)
Amylase |
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Term
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Definition
| Catalyze removal of groups from substances with out hydrolysis |
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Term
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Definition
| Catalayze Interconversion of Isomer |
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Term
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Definition
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Term
|
Definition
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Term
|
Definition
| Similar to normal substrate competes for active site |
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Term
| What are the 5 factors infulencing Enzyme Action |
|
Definition
1. Enzyme COncentration
2. Temperature
3. pH
4. Cofactors
5. Inhibitors |
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Term
|
Definition
| Velocity is directly proportional to subrate concentration |
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Term
|
Definition
| Rxn rate us independent of substrate concentration |
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Term
| Three properties of enzyme |
|
Definition
1. Ezymes are not altered or consumer in the rxn
2. Only a small amount of ezymes are used in the rxn
3. Ezymes acclerrate the speed of the rxn |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
| Organic/inorganix compounds need in enzyme fxns |
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Definition
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Term
|
Definition
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Term
|
Definition
Biliary obstruction
Acute pancreatitis
Help differntiate b/w liver and bone disease |
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Term
| catalyzes the hydrolysis of complex carbohydrates including starch, amylopectin, glycogen |
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Definition
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Term
| Enzymes where acute pancreatitis is the issue |
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Definition
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Term
|
Definition
timing of draw
type of anticoagulant
lipemia or icterus for some specimens
serum vs. plasma
serum vs. plasma vs. whole blood |
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