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Clin Lab
Lecture 2-Blood Components
18
Pathology
Graduate
09/13/2009

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Cards

Term
Red Blood Cell Indices
Definition
Mean Corpuscular Volume (MCV)
Mean Corpuscular Hemaglobin (MCH)
Mean Corpuscular Hemoglobin Concentration (MCHC)
Term
Mean Corpuscular Volume (MCV)
Definition
Measure of the size or volume of the average RBC
may be high or low in the absence of true anemia
Alcoholism
Megaloblastic Anemia (early)
Drug induced Marcocytosis

Based on the MCV anemia is classified as:
Microcytic
Normocytic
Marcocytic
Term
Microcytic
Definition
decrease in RBC volume (<80 fL)
Most common cause is iron deficiency
Term
Normocytic
Definition
Normal RBC volume (80 – 96 fL)
Term
Macrocytic
Definition
Elevation in RBC volume (> 96 fL)
Most common cause is alcoholism
Term
Mean Corpuscular Hemoglobin (MCH)
Definition
Weight of HB in the average cell
Reference range (26 – 34 pg)
Changes parallel the MCV
Term
Mean Corpuscular Hemoglobin Concentration (MCHC)
Definition
The amount of hemoglobin in the average RBC when compared to its size
Men
31 to 37 g/dL
Women
30 to 36 g/Dl

50% of patients with hereditary spherocytosis
Have a MCHC >36 g/dL
Term
RBC Distribution
Definition
Measure of the size variability of RBCs
Anisocytosis
Common in many types of anemia
An increased RDW may precede an abnormality in Hb or MCV
Microcytosis
Normocytosis
Macrocytosis
Term
Microcytosis (Normal RDW)
Definition
Thalassemia Minor
Anemia of Chronic Disease
Term
Microcytosis (High RDW)
Definition
Iron Deficendy
Hemoglobin H disease
Some Anemic of Chronic Disease
Some Thalassemia Minor
Fragmentation Hemolysis
Term
Normocytosis (Normal RDW)
Definition
Anemia of Chronic Disease
Hereditary Spherocytosis
Some hemoglobinopathy
Acute bleeding
Term
Normocytosis (High RDW)
Definition
Early or partially treated Fe or vitamin deficiency
SCA
Term
Macrocytosis (Normal RDW)
Definition
Aplastic Anemia
Some Myelodysplasias
Term
Macrocytosis (High RDW)
Definition
Vit B12 Deficiency
Folate deficiency
Autoimmune Hemolytic Anemia
Cold agglutinin disease
Liver or Thyroid disease
Alcohol
Term
Peripheral Blood Smear
Definition
Should be examined when CBC is abnormal(get a manual dip)
May reveal clues to the etiology of the anemia
Reveals
Anisocytosis – variation of cell size
Poikilocytosis – variation of cell shape
Term
Reticulocytes
Definition
RBCs that are larger than normal RBCs and appear polychromatic, they are immature RBCs produced in response to an anemic state
Term
Polychromasia
Definition
Grayish-blue color of the cytoplasm in reticulocytes caused by ribosomes
Term
Ribosome
Definition
a cell organelle made of ribosomal RNA and protein
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