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Study history, sources, physical & chemical properties of drugs
Interaction between chemicals/drugs and how affect living systems |
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| 4 subdivisions of pharm 1.2.3.4.clinical pharmacology; |
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| 1.pharmacokinetics 2.pharmacodynamics 3.pharmacotherapeutics 4.toxicology |
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| clinical pharmacology; branch that uses drugs treat, prevent, & diagnose disease. |
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| mechanism action & biochemical/physical effects(how drug affects the body) |
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| absorption, distribution, metabolism and excretion (how the body affects the drug) |
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| toxicity and adverse reactions (subdivision) |
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| drugs scheduled I are ______ for abuse, but V are _____for abuse |
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1. category __ drugs Demonstrate fetal abnormalities or fetal risk
2. category __ drugs are no risk to fetus |
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| 4 parts of pharmacokinetics |
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| 1. absorption 2. distribution 3. biotransformation (metabolism) 4. excretion |
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| Rate which & extent drug moves from site of administration. |
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categories of distribution
1.absorbed bloodstream attach plasma proteins & then transported reactive tissues
2. 3. |
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| 1.plasma binding 2. blood-brain barrier 3. placenta or breast milk |
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| biotransformation before the drug reaches general circulation |
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| hepatic first-pass effect |
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| most important route of excretion (its an organ) |
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Study biochemical & physiological effects DRUGS on body and includes receptor
interactions, therapeutic & toxic actions, with dose-response.
aka study of drugs mechanism of action |
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| Metabolism of drug & it’s passage from liver into circulation |
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ime it takes for amount of drug in body to decrease to one-half of peak level it previously achieved.
• If start with 100mg/dl and 1⁄2 life is 4 hours then 50mg/dl left at 4 hours!
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medication effects
1.start
2.highest blood level
3.therapeutic response
4.lowest blood level |
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Definition
1. onset
2. peak
3. duration
4. trough level |
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| Study of which drug would be most/least appropriate to use for specific disease or illness. |
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selected by manufacturer. first letter trade name is capital
EX:Superscript ® registered U.S. Patent Office & approved FDA (Food & Drug Administration) |
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| derived chemical name name remains same all countries |
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| based chemical composition & molecular structure |
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| how to take ear drop medications: instill ear drops by pulling ears ____ up and back |
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how to administer eye drops:
1.Administer drops into ________
2.Administer ointment inside ____ of lower lid |
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Definition
1. conjunctival sac
2. edge of lower lid |
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