Term
| Why do we need dosage adjustments in kidney disease? |
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Definition
- Prevent drug accumulation (adverse drug reactions, drug side effects)
- Prevent medication errors
- Reduce drug cost from excessive use
- Maintain therapeutic drug levels |
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Term
| Who is a prime candidate for dose adjustments, and what drug properties are affected? |
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Definition
- CKD patients and AKI patients
- ADME is affected (Absorption, Distribution, Metabolism, Excretion) |
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Term
| If absorption is affected than it will also affect bioavailability. What are some examples of this? |
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Definition
- GI Transit time and gastric pH will be affected (affects Ketoconazole)
- Edema of the GI tract can occur (use lasix
- Vomitting and diarrhea occur
- Decreased first pass (Beta Blockers)
- Gastroparesis
*Rate of absorption and the amount to be absorbed is reduced. |
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Term
| In CKD, as Vd increases, what happens to protein binding of the drug? |
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Definition
| It decreases, leaving more drug unbound at site of action. However, more susceptible to metabolism and excretion than before. |
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