Term
| how is pyruvate converted to alanine? |
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Definition
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Term
| how is pyruvate converted to oxaloacetate? |
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Definition
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Term
| how is pyruvate converted to acetyl CoA? |
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Definition
| oxidative decarboxylation |
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Term
| how is pyruvate converted to lactate? |
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Definition
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Term
| what is acetyl coA the common product of |
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Definition
| carbohydrate, amino acid, and FA breakdown |
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Term
| The majority of regulatory mechanisms target this part of the PDC complex. |
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Definition
| E1, the actual pyruvate dehydrogenase enzyme. |
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Term
| one acetyl group is oxidized to form what |
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Definition
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Term
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Definition
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Term
| How many GTP are produced |
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Definition
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Term
| Where do the abstracted electron pairs go after the tca cycle? |
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Definition
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Term
| how many ATPs are produced in a turn of the Citric acid cycle |
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Definition
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Term
| Fluoroacetate inhibits what in the citric acid cycle? |
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Definition
| stops the aconitase enzyme b/t citrate and cis-aconitase. this leads to a build up of citrate which deprives the cell of energy. |
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Term
| how does malonate affect the TCA cycle? |
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Definition
it binds to the active site of succinate dehydrogenase and does not act.
it is a competitive inhibitor with succinate |
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Term
| what is the effect of arsenite on the TCA? |
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Definition
| arsenite covalently binds to sulfhydryl groups and inactivates the PDC and a-ketoglutarate dehydrogenase. |
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Term
| what reaction replenishes intermediates of the TCA cycle? |
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Definition
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Term
| in the anaplerotic reactions, what is pyruvate replenished with? |
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Definition
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Term
| oxaloacetate is replaced with what in anaplerotic pway |
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Definition
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Term
| fumarate is replenished with what |
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Definition
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Term
| what is FAD a cofactor in? |
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Definition
| pyruvate and a-ketoglutarate |
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Term
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Definition
| three dehydrogenases in cycle and PDC |
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Term
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Definition
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Term
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Definition
| carboxylation reactions (pyruvate carboxylase) |
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Term
| what is thiamine pyrophosphate |
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Definition
| coenzyme for the pyruvate and a-ketoglutarate dehydrogenase reactions |
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Term
| What can thymine deficiency lead to? |
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Definition
loss of appetite, constipation, and nausea which leads to depression and peripheral neuropathy. also alcholic syndrome.
can also lead to beri beri |
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