Term
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Definition
- acetyl CoA to citrate.
- ligation / condensation reaction.
- sequential ordered mechanism: oxaloacetate reacts first and creates a new active site for acetyl CoA
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Term
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Definition
- citrate to isocitrate - isomerisation.
- dehydration and hydration reactions.
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Term
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Definition
- isocitrate to alpha-ketoglutarate.
- makes NADH.
- decarboxylation and oxidation reaction.
- up regulated by ADP, down by ATP and NADH
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Term
| alpha-ketoglutarate dehydrogenase complex |
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Definition
- alpha-ketoglutarate to succinyl coA.
- makes NADH.
- uses Coenzyme A, FAD, TPP.
- 3 subunits.
- decarboxylation and oxidation reactions.
- down reg by succ. CoA, ATP, NADH
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Term
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Definition
- succinyl CoA to succinate.
- makes GTP and CoA.
- substrate-level phophorylation reaction.
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Term
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Definition
- succinate to fumarate.
- makes enzyme bound FADH2 from enzyme bound FAD.
- oxidation reaction.
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Term
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Definition
| fumarate to malate. Uses water - hydration reaction. |
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Term
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Definition
- malate to oxaloacetate.
- Makes NADH.
- oxidation reaction.
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Term
| calculating ATP produced from one glucose. |
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Definition
- FADH2 = 1.5 ATP
- NADH = 2.5 ATP
- GTP = ATP
- glycolysis: 3-5 ATP from NADH; 4 net ATP.
- 2 pyruvate produced.
- NADH from PDH, isocitrate DH, alpha-KG DHC, malate DH.
- Get GTP from succinyl CoA synthetase.
- Get FADH2 from succinate DH.
- TOTAL 30-32 ATP
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Term
| biosynthetic precursors produced |
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Definition
citrate: for fatty acids, sterols.
alpha-ketoglutarate: for glutamate (amino acids and purineS)
succinyl CoA: for heme, chlorophyll
oxaloacetate: for acetate (amino acids, purines, pyrimidines.) |
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