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Circulatory Disturbance
pathology 3610
32
Pathology
Undergraduate 3
02/11/2014

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Term
Components of Blood
Definition
-Red Blood Cells (RBC)
-White Blood Cells (WBC)
-Plasma (serum plus clotting proteins)
-Serum (Fluid)
Term
Capillary Bed
Definition
Arteriole, Capillary, Venule
-Regulated by precapillary sphincter
Term
Capillary
Definition
-more room in the capillary than blood volume
-endothelial cells line the walls
-at any time only a small percentage are open
Term
Starling Forces of Hemodynamics
Definition
-high pressure at arteriole end
-low pressure at venule end
-oncotic pressure similar to osmotic determined by proteins (albumin)
-hydrostatic pressure forces fluid outside of capillary (cell stay in)
-ontic pressure rises, sucks fluid back into capillary
-excess fluid is taken away by the lympathic vessels
Term
Oedema (Edema)
Definition
-When we have to much fluid
-not enough oncotic pressure to suck the fluid back into the capillaries
-causes inflammation
increased venous hydrostatic pressure
-causes heart failure
reduced oncotic pressure
Term
Ascites
Definition
fluid in abdominal cavity
Term
peripheral oedema
Definition
feet swell up
Term
Hyperemia
Definition
increased blood circulation in capillaries
-signal by percapillary sphincter
-blood fills up
Term
Congestion
Definition
-opposite of hyperemia
-passive process, post-capillary obstruction
-edema =congestion
Term
Putting pressure on your finger, will go red, obstructing veins, start filling with venous blood, results in?
Definition
Lots of edema (congestion)
Term
Ischeamia
Definition
stopping of blood, reduced flow of blood, infraction
Term
Heamatoma
Definition
blood blister (oma=swelling)
Term
Infarction
Definition
-death of tissue due to ischaemia
-venous (red) or arterial (white)
-end-artery systems (no collateral; heart, brain, kideny)
Term
ecchymosis
Definition
hickey
Term
petechia
Definition
pin point heamorrhage
Term
diapedesis
Definition
red blood cells leak out of vessels
Term
Coagulation
Definition
clot
post-mortem clot
thrombus
Term
Thrombus
Definition
blood clot inside a vessel
Term
Normal Hemostasis
Definition
prevention of bleeding
-endothelial cells (line blood vessels, regulate blood flow)
Term
Coagulation protein
Definition
enzymes catalyze reactions to activate next step
-Fibrin (protein clot)
Term
Platelets
Definition
Controls where blood will clot or not
Term
Measurement of Hemostasis
Definition
platelets = bleeding time, platelet count
Intrinsic
Extrinsic
Term
Intrinsic
Definition
how long it takes blood to clot when stimulated
Term
Extrinsic
Definition
(PT = prothrombin time)
Term
Pulmonary Thrombus
Definition
lump of protein in a vessel with fibrin
-occurs in lungs
Term
Thrombogensis
Endothelial injury
Definition
-atherosclerosis
-severe trauma
-surgery
Term
Thrombogenesis
Altered blood flow
Definition
stagnation,
turbulence
deep vein thrombosis
Term
Thrombogenesis
Hypercoaguability
Definition
(increased likelihood of clotting)
-Smoking
-Obesity
-Cancer
Term
Embolism
Definition
foreign substance moving in the blood
-thrombotic (blood clot in vessel)
-gas (scuba diver)
-air
-marrow (break a bone)
-neoplastic (cancer)
Term
Shock
Definition
- wide spread hypoperfusion of tissues and cells
- Neurogenic, hypovolemic, cardiogenic, septic, anaphylatic
Term
cardiogenic
Definition
after heart attack, heart stops pumping
Term
Septic
Definition
bad response to infection, not enough blood
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