Term
| Does acetylation and methylation just activate and silence? |
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Definition
| While that is generally the case, they can do the opposite |
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Term
| what causes the silencing when somehting is methylated? |
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Definition
| it is not the methylation per se that causes the cessation of transcription, rather its what binds to the methylated group that determines its activity |
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Term
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Definition
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Term
| How to activate (repress) chromatin for transcription |
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Definition
- covalently modify histone termini: H3 lysine 9 acetylation/methylation
- use histone modifications to recruit open proteins
- move nucleosomes out of or into the way of the promoter
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Term
| How do modifyig enzymes create binding sites |
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Definition
a) histone acetylase (HAT) which causes binding of a second activator protein b) bromodomain (reconize acetylysine) subunit of TFIID. This is much more attracted to regions that have undergone acetylation. |
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