Term
| What are the three useful effects of COX inhibitors? |
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Definition
1. inflammation suppression
2. pain relief
3. fever reduction |
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Term
| What is cyclooxygenase (COX)? |
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Definition
| the enzyme that converts arachidonic acid into prostanoids, prostablandins and related compounds. |
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Term
| What is the difference between COX-1 and COX-2? |
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Definition
| COX-1 is found in nearly every tissue in the body while COX-2 is present at sites of tissue injury, in the brain, in the kidney, blood vessels and colon. |
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Term
| What does inhibition of COX-1 do? Is this a positive or negative effect? |
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Definition
Benefit: protection against MI and stroke secondary to reduced platelet aggregation
Detriment: gastric erosion and ulceration, bleeding tendencies, renal impairment |
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Term
| What does inhibiting COX-2 do? Is this a benefit? |
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Definition
Benefit: suppression of inflammation, alleviation of pain, reduction of fever, protection against colorectal cancer
Detriment: Renal impairment, promotion of MI and stroke secondary to suppressing vasodilation |
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