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Cholinergics
Neuro Exam #1
18
Pharmacology
Graduate
10/03/2011

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Cards

Term
Bethanechol
Definition
Muscarinic AGONIST
Ester -> AChE susceptible
4' ammonium, B-methyl
Promote GI/urinary motility
Term
Pilocarpine
Definition
Muscarinic AGONIST
NOT an Ester -> NOT AChE susceptible
3' amine, B-methyl
^ Secretions, Miosis
Term
Atropine
Definition
Muscarinic ANTAGONIST
3' amine
Treat agonist toxicity, Mydriasis
Term
Scopolamine
Definition
Muscarinic ANTAGONIST
WELL-ABSORBED
Transdermal antiemetic patch
Term
Benztropine
Definition
Muscarinic ANTAGONIST
3' amine
GOOD CNS penetration
Treat PD
Term
Tolterodine
Definition
Muscarinic ANTAGONIST
3' amine
M3 Selective
Treat urinary incontinence
Term
Ipratropium
Definition
Muscarinic ANTAGONIST
4' ammonium
Inhaled for asthma/COPD
Term
Tropicamide
Definition
Muscarinic ANTAGONIST
3' amine
SHORT duration
Mydriasis/Cycloplegia
Term
Succinylcholine
Definition
Nicotinic Depolarizing NMB
Induces short-term paralysis
Term
Tubocurarine
Definition
Nicotinic Nondepolarizing NMB
HIGHLY Polar
Administered parenterally
Term
Pancuronium
Definition
Nicotinic Nondepolarizing NMB
HIGHLY Polar
Administered parenterally
Term
Edrophonium
Definition
AChE Inhibitor
Alcohol with 4' ammonium
Used for diagnosis of MG
Term
Neostigmine
Definition
AChE Inhibitor
Carbamate
Treat MG, Ileus, reverse NMB
Carbamoylates AChE
Term
Physostigmine
Definition
AChE Inhibitor
Carbamate
Treat glaucoma, reverse NMB
Carbamoylates AChE
WELL-ABSORBED with CNS
Term
Pyridostigmine
Definition
AChE Inhibitor
Carbamate
Treat MG
Carbamoylates AChE - LONG Duration
Term
Echothiophate
Definition
AChE Inhibitor
Organophosphate
Treat glaucoma, POOR Absorption, LONG Duration
Phosphorylates AChE (may AGE!)
Term
Pralidoxime
Definition
Reverses effects of Organophosphates
Hydrolyzes phosphate on AChE
ONLY works if inhibitor has NOT AGED!
Term
Tacrine
Definition
AChE Inhibitor
Treat Alzheimer's
Hepatotoxic
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