Term
| Muscarinic M1 Cholinergic Receptor's Typical Location |
|
Definition
| CNS neurons, some presynaptic sites |
|
|
Term
| Muscarinic M2 Cholinergic Receptor's Typical Location |
|
Definition
| Myocardium, smooth muscle |
|
|
Term
| Muscarinic M3 Cholinergic Receptor's Typical Location |
|
Definition
| Exocrine glands, vessels (smooth muscle and endothelium) |
|
|
Term
| Muscarinic M4 Cholinergic Receptor's Typical Location |
|
Definition
| CNS neurons, vagal nerve ending |
|
|
Term
| Muscarinic M5 Cholinergic Receptor's Typical Location |
|
Definition
| Vascular endothelium, especially cerebral vessels; CNS neurons |
|
|
Term
Nicotinic Nn Cholinergic Receptor's
Typical Location |
|
Definition
| Postganglionic neurons, some presynaptic cholinergic terminals |
|
|
Term
Nicotinic Nm Cholinergic Receptor's
Typical Location |
|
Definition
| Skeltal muscle neuromuscular end plates |
|
|
Term
Muscarinic M1 Cholinergic Receptor's
Result of Ligand Binding |
|
Definition
| Formation of IP3 and DAG, Increased intracellular Ca+2 |
|
|
Term
Muscarinic M2 Cholinergic Receptor's
Result of Ligand Binding |
|
Definition
| Inhibition of adenylate cyclase, opening K+ channels |
|
|
Term
Muscarinic M3 Cholinergic Receptor's
Result of Ligand Binding |
|
Definition
| Like M1 Ligand Binding: Formation of IP3 and DAG, Increased intracellular Ca+2 |
|
|
Term
Muscarinic M4 Cholinergic Receptor's
Result of Ligand Binding |
|
Definition
| Like M2 Ligand Binding: Inhibition of adenylate cyclase, opening K+ channels |
|
|
Term
Muscarinic M5 Cholinergic Receptor's
Result of Ligand Binding |
|
Definition
| Like M1 Ligand Binding: Formation of IP3 and DAG, Increased intracellular Ca+2 |
|
|
Term
Nicotinic Nn Cholinergic Receptor's
Result of Ligand Binding |
|
Definition
| Opening of Na+, K+ channels, depolarization |
|
|
Term
Nicotinic Nm Cholinergic Receptor's
Result of Ligand Binding |
|
Definition
| Opening of Na+, K+ channels, depolarization |
|
|
