Term
|
Definition
| Blocks entry of choline into cell- so anticholinergic? |
|
|
Term
|
Definition
| Blocks uptake of ACh into vesicles |
|
|
Term
|
Definition
Blocks release of ACh vesicles
- removal of 2 AAs from synaptobrevin- prevents vesicle fusion
- Uses: strabismus, estropia, frown lines, stroke paralysis, migraines, stuttering, incontinence, club foot, etc |
|
|
Term
|
Definition
- neural
- only on parasympathetic postsynaptic
- increases IP3 and DAG, affecting Ca levels |
|
|
Term
|
Definition
- cardiac
- only on para post
- decreases HR, contractility, and conduction by decreasing cAMP and increasing K efflux |
|
|
Term
|
Definition
- glandular
- eye, GI, bladder, bronchoconstrition
- via IP3, DAG, Ca |
|
|
Term
|
Definition
- muscarinic agonist
- treats flaccid abdomen, urinary retention
- adverse effects: bronchospasms, increased exocrine secretions |
|
|
Term
|
Definition
- muscarinic agonist
- treats glaucoma, dry mouth
- adverse effects: bronchospasms, increased exocrine secretions |
|
|
Term
|
Definition
- At lose doses, simulates nicotinic receptors
- smoking cessation
- at high doses, it can inhibit NR and cause death |
|
|
Term
|
Definition
- acts only on ACh
- located on membrane |
|
|
Term
|
Definition
- in plasma, intestine, skin, etc
- acts on ACh, benzylcholine, succinylcholine
- located in plasma |
|
|
Term
| Examples of organophosphates |
|
Definition
- glaucoma drugs- isoflurophate, echothiophate
- nerve gas
- insecticides- parathion, malathion |
|
|
Term
| Area obstructed in chronic glaucoma |
|
Definition
|
|
Term
|
Definition
- inhibits AChE (5-10 minutes)
- used to diagnose myasthenia gravis
- can cause cholinergic crisis
- short acting anticholinesterase drug |
|
|
Term
|
Definition
- inhibits AChE
- treats Alzheimers
- Adverse effects: insomnia |
|
|
Term
|
Definition
- inhibits AChE
- treats myasthenia gravis
- can cause cholinergic crisis |
|
|
Term
|
Definition
- irreversible inhibitor of AChE
- treats glaucoma, estropia
- can cause cholinergic crisis |
|
|
Term
|
Definition
- reactivates AChE
- treats cholinergic crisis (with atropine)
- can cause blurred vision, tachycardia, dizziness |
|
|
Term
|
Definition
- resistant to cleavage by AChE
- direct ACh receptor agonist |
|
|
Term
|
Definition
|
|
Term
| medium - acting anticholinesterase drugs |
|
Definition
neostigmine, physostimine
Treat myasthenia gravis
Same category as pyridostigmine
Neostigmine doesn't cross BBB, physostigmine does |
|
|
Term
|
Definition
muscarinic agonist
use in glaucoma (like pilocarpine) |
|
|
Term
|
Definition
- muscarinic agonist
- for treatment of asthma |
|
|
Term
| Contraindications of cholinergic agonists |
|
Definition
| PUD, CAD, asthma, hyperthyroidism |
|
|
