Shared Flashcard Set

Details

Cholinergic Agonists
BCM Pharmacology 2011
8
Pharmacology
Graduate
01/25/2011

Additional Pharmacology Flashcards

 


 

Cards

Term
Bethanechol-Mechanism? Half-life? Clinical Use? Application?
Definition
Preferential Muscarinic Agonist, Quaternary amine
1 HR
Treats Urinary retention & Xerostomia
Subcutaneous or Topical
Term
Carbachol-Mechanism? Half-life? Clinical Use? Application?
Definition
gen ACh receptor agonist, Quaternary amine
1-2 HR
Treats Glaucoma, induces miosis for ocular surgery
Topical
Term
Pilocarpine-Mechanism? Half-life? Clinical Use? Application?
Definition
Preferential Muscarinic Agonist, Tertiary amine
24 HR
Treats acute Glaucoma
Topical
Can enter CNS
Term
Cholinergic Adverse Effects:
Definition
Diarrhea
Urination
Miosis
Brochoconstriction
Bradycardia
Excitation of muscles/CNS
Lacrimation
Salivation
Sweating
Term
Edrophonium-Mechanism? Half-life? Clinical Use?
Definition
reversible ACh esterase inhibitor at NMJ, 5-10 min, diagnosis only of myasthenia gravis
Term
Neostigmine, Pyridostigmine-Mechanism? Half-life? Clinical Use?
Definition
reversible ACh esterase inhibitor at NMJ, 2-4 HR/4-6HR, treatment of myasthenia gravis (but causes muscle weakness in normal people) open-angle glaucoma and reversal of nondepolarizing neuromuscular blockade following surgery
Term
Physostigmine-Mechanism? Half-life? Why special?
Definition
reversible ACh esterase inhibitor, 15-40 min, tertiary amine & enters CNS; not for peripheral use
Term
Isofluorophate, echothiophate-Mechanism? Clinical Use? Timeframe? Where else found?
Definition
irreversible ACh esterase inhibitor (phosphorylate it, antidote=PAM/atropine) Treat chronic glaucoma-one app lasts a week. Found in insecticides & nerve gas
Supporting users have an ad free experience!