Term
| CHOLINOMIMETIC agents/agonists |
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Definition
Drugs that mimic Acetylcholine
Direct Acting: Bind directly to ACh receptors
Indirect Acting: inhibit degradation of ACh |
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Term
| Acetylcholine Agonist Sites |
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Definition
At all muscarinic receptors
At all ganglia: Nn receptors
At all somatic neuromuscular junctions:Nm |
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Term
| MUSCARINIC receptor sites |
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Definition
Heart and smooth muscle
Glands and endothelium
Nerve |
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Term
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Definition
All autonomic ganglia
Neuromuscular end plate
Skeletal Muscle |
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Term
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Definition
| Reduction in pupil size caused by the contraction of the pupillary constrictor muscle (muscarine receptor-mediated) |
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Term
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Definition
Used for smoking cessation therapy
Agonist at both Nm and Nn receptors
Can enter CNS |
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Term
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Definition
| Plant Alkyloid similar to nicotine |
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Term
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Definition
| Selective partial agonist at nicotinic receptors; triggers partial dopamine release in CNS |
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Term
| Nicotinic Systemic Pharmacological Effects |
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Definition
| Think about activation of the nerve ganglia and skeletal muscle end plate |
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Term
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Definition
| Tremors,Convulsions,Respiratory stimulation or depression, Release ofantidiuretic hormone from the pituitary gland, NauseaEmesis |
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Term
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Definition
MIOCHOL
quaternary ammonium group limits drug to local effects
opthalmic solution for pupil contraction
cardiac vasodilation |
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Term
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Definition
Less susceptible to AChesterase
All muscarinic action, no nicotinic stimulation
No skeletal muscle spasms
Diagnoses bronchial hyperactivity |
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Term
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Definition
Pure muscarinic agonist that spurs a parasympathetic response w/o skeletal spasms
NOT given IV
Used to increase GI movement and bladder contractions |
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Term
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Definition
Muscarinic receptor agonist
Used to contract ciliary bodies to treat open angle glaucoma
- Used only in pt. non-responsive to pilocarpine |
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Term
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Definition
Choline esters of carbamic acid
Greater muscarinic selectivity
Longer half life |
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Term
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Definition
Pure muscarinic alkaloid agonist
Not degraded by ACHesterase
Causes miosis,salivation, used for wide angle glaucoma, ocular HTN
Dosed in ocular reservoir to avoid systemic affects (can cross membranes) |
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Term
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Definition
Synthetic Muscarinic Agonist
Major M3 and M1 action
Used to treat dry mouth (Sjogren's) |
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Term
| Optical Side Effects of Para drugs |
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Definition
Engorged blood vessels
Inability to focus
Clouding of the lens |
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Term
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Definition
1:Nerves
2:Heart, nerves, smooth muscle
3:Glands, smooth muscle, epithelium
4&5: CNS |
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