Term
|
Definition
| Non-selective agonist. Little use. Rapid induction of miosis. |
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|
Term
|
Definition
| Mostly muscarinic agonist. Some AChE resistance. Rarely used. |
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Term
|
Definition
| Non-selective agonist. Not AChE substrate. Tx: glaucoma. |
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|
Term
|
Definition
| Mostly muscarinic (M1) agonist. Causes sweating. Tx: glaucoma. |
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|
Term
|
Definition
| Muscarinic agonist. Tx: post-op/post-partum non-obstructive urinary retention. |
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|
Term
|
Definition
| AChE antagonist. Tx: myasthenia gravis sxs, nondepolarizing neuromuscular blocker antidote, post-op urinary retention. Adverse: arrhythmia, inc secretions, urinary urgency & freq. |
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|
Term
|
Definition
| AChE antagonist. Tx: myasthenia gravis differential dx, non-depol neuromusc blocker antidote. |
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Term
|
Definition
| AChE antagonist IN CNS. Tx: reverse muscarinic antagonists & sedatives. |
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|
Term
| Tacrine, donepezil, rivastigmine, galantamine |
|
Definition
| AChE antagonist--LONG ACTING. Tx: Alzheimer's. |
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|
Term
|
Definition
| IRREVERSIBLE AChE antagonist. Tx: glaucoma, insecticides. |
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Term
|
Definition
| Muscarinic R agonist. Tx: many uses (think anti-parasympathetics). Warning: determine intraocular press before ophthalmic use to avoid glaucoma attacks. |
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|
Term
|
Definition
| Muscarinic R antagonist on bronchial sm musc. Tx: bronchospasm |
|
|
Term
|
Definition
| Muscarinic R antagonist on GIT. Tx: adjunct in peptic ulcer. Warning: glaucoma, CHF. |
|
|
Term
|
Definition
| Muscarinic R antagonist. Sedation & amnesia in obstetrics (no more). |
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|
Term
|
Definition
| Muscarinic (partially M1 selective) antagonist in auto ganglia. Tx: (not-US) gastric ulcers |
|
|
Term
|
Definition
| Muscarinic (M3 SELECTIVE) antagonist. Tx: urinary urgency. |
|
|
Term
|
Definition
| Nicotine R agonist. Tx: smoking cessation. |
|
|
Term
|
Definition
| Niconine R partial agonist. Tx: smoking cessation. |
|
|
Term
|
Definition
| Nicotinic R antagonist (partially autonomic gang selective). Tx: (not anymore) HTN |
|
|
Term
|
Definition
| Nicotinic R antagonist. Ultra-short acting gang blocker. Tx: post-op bleeding, hyperreflexia, hypertensive emergencies when B blocker contraindicated. |
|
|
Term
|
Definition
| NON-COMPETITIVE Nicotinic antagonist in CNG. Tx: same as trimethaphan, nicotine dependence? |
|
|
Term
|
Definition
| Depolarizing/sensitizing Neuro-musc jxn antagonist. Rapid onset, short duration, metabolized by PSEUDOCHOLINESTERASE. |
|
|
Term
|
Definition
| Non-depolarizing neuro-muscular jxn antagonist. Can partially block auto gang--> hypotension. HISTAMINE release. |
|
|
Term
|
Definition
| Non-depolarizing neuro-muscular jxn antagonist. Long-acting. No CV side effects. |
|
|
Term
|
Definition
| Non-depolarizing neuro-muscular jxn antagonist. Most rapid onset. High dose--> antimuscarinic. |
|
|
Term
|
Definition
| Non-depolarizing neuro-muscular jxn antagonist. Some histamine release. Inactivated w/o enzyme. |
|
|
Term
|
Definition
| Non-depolarizing neuro-muscular jxn antagonist. Hydrolyzed by PSEUDOCHOLINESTERASE. |
|
|
Term
|
Definition
| Skeletal musc relaxant. GABA derivative. Tx: spasticity (from MS, trauma). Adverse: Drowsiness, weakness, w/drawl--> seizures. |
|
|
Term
|
Definition
| Skeletal musc relaxant. Facilitates GABA binding. tx: joint disease or muscle spasm. Adverse: sedation |
|
|
Term
|
Definition
| Skeletal musc relaxant. Dec amt of Ca++ release from SR (esp in reflex). Tx: spasticity, MS, MALIGNANT HYPERTHERMIA. |
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