Term
| What is the MOA of Chloramphenicol? |
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Definition
Binds to 50s ribosomal subunit
inhibits peptidyl transferase |
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Term
| When is Chloramphenicol used? |
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Definition
| Salmonella typhi - when 3rd generation cephalosprins are not available (developing countries) |
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Term
| What are the ADR's of Chloramphenicol & why? |
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Definition
Bone marrow supression
Aplastic anemia
Grey baby syndrome - due to the lack of glucuronic acid conjugation - a mechanism of degradation and detoxification of chloramphenicol, which is not yet fully developed in babys. |
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Term
What is the first line drug for S.typhi?
WHat s given when this is not available? |
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Definition
1 - 'one & one' (3 generation drug of cephalosporins)
2 - Chloramphenicol |
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Term
How would you treat B.frggilis
what would you give if this is not avaliable? |
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Definition
1 - second generation cephalosporins 'Xitin & tetan'
third generation Cftizoxine
2. Chloramphenicol |
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