Diuretics

Furosemide (Lasix®)

Hydrochlorothiazide (Esidrix®, Hydro-DIURIL®)

Furosemide

Lasix®

MOA: Decreases NaCl and KCl reabsorption in the thick ascending limb of the loop of Henle in the nephron

Diuretic (Loop)

Hydrochlorotiazide

Esidrix®, Hydro-DIURIL®

MOA: Decreases NaCl reabsorption in the distal convoluted tubule

Diuretic (Thiazide)

Aldosterone Receptor Antagonists

Spironolactone (Aldactone®)

Eplerenone (Inspra®

Spironolactone

Aldactone®

MOA: Binds to the receptor preventing aldosterone binding to the receptor (mineralcorticoid receptor) prevents reabsorption of sodium, chloride, and water, therefore excretion occurs

SE: Unwanted hormonal effects

Aldosterone Receptor Antagonist

Eplerenone

Inspra®

More selective antialdosterone effects

Less hormonal side effects than Spironolactone

Aldosterone Receptor Antagonist

ACE Inhibitors

Captopril (Capoten®)

Fosinipril (Monopril®)

Enalapril (Vasotec®)

Benazepril (Lotensin®)

Lisinopril (Prinivil®, Zestril®)

Moexipril (Univasc®)

Perindopril (Aceon®)

Quinapril (Accupril®)

Ramipril (Altace®)

Trandolapril (Mavik®)

Captopril

Capoten®

Only ACE Inhibitor take 2-3 times a day

ACE Inhibitor (Sulfhydryl-containing)

Fosinopril

Monopril®

ACE Inhibitor (Phosphate-containing)

Enalapril

Vasotec®

ACE Inhibitor (Dicarboxylate-containing)

Benazepril

Lotensin®

ACE Inhibitor (Dicarboxylate-containing)

Lisinopril

Prinivil®, Zestril®

ACE Inhibitor (Dicarboxylate-containing)

Moexipril

Univasc®

ACE Inhibitor (Dicarboxylate-containing)

Perindopril

Aceon®

ACE Inhibitor (Dicarboxylate-containing)

Quinapril

Accupril®

ACE Inhibitor (Dicarboxylate-containing)

Ramipril

Altace®

ACE Inhibitor (Dicarboxylate-containing)

Trandolapril

Mavik®

ACE Inhibitor (Dicarboxylate-containing)

Angiotensin Receptor Blockers

(ARBs)

Losartan (Cozaar®)

Candesartan (Atacand®)

Eprosartan (Teveten®)

Irbesartan (Avapro®)

Olmesartan (Benicar®)

Telmisartan (Micardis®)

Valsartan (Diovan®)

Losartan

Cozaar®

ARB

Candesartan

Atacand®

ARB

Eprosartan

Teveten®

ARB

Irbesartan

Avapro®

ARB

Olmesartan

Benicar®

ARB

Telmisartan

Micardis®

ARB

Valsartan

Diovan®

ARB

Beta Blockers

Bisoprolol (Zebeta®)

Carvedilol (Coreg®)

Metoprolol (Lopressor®, Toprol® XL)

Bisoprolol

Zebeta®

Beta Blocker (B1 Selective)

Carvedilol

Coreg®

Beta Blocker (Nonselective B & A1 blocker)

Metoprolol

Lopressor®, Toprol® XL

Beta Blocker (B1 selective)

Cardiac Glycosides

Digoxin (Lanoxicaps®, Lanoxin®)

MOA: Inhibits sodium-potassium ATPase, causes stronger contractions of the heart muscle because of an increase in intracellular calcium

Digoxin

Lanoxin®, Lanoxicaps®

Cardiac Glycosides

Vasodilators

Isosorbide DN (Isordil®)

Hydralazine (Apresoline®)

Nitroprusside (Nitropress®)

Isosorbide DN

Isordil®

Vasodilator (Venodilator)

Hydralazine

Apresoline®

Vasodilator (Arteriolar dilator)

Nitroprusside

Nitropress®

Vasodilator (Combination)

PDE-3 Inhibitors

Inamrinone (Inocon®)

Milrinone (Primacor®)

MOA: Block PDE to increase cAMP which leads to an increase in myocardial contractility

Inamrinone

Inocon®

PDE-3 Inhibitor

Milrinone

Primacor®

Drug of choice in this class becuase it has a shorter half life

PDE-3 Inhibitor

Adrenergics

Dobutamine

Dopamine (Intropin®)

These drugs are catecholamines, they are sympathomimetics

Dobutamine

No brand name

Adrenergic

Dopamine

Intropin®

Adrenergic

Natriuretic Peptide

Nesiritide (Natrecor®)

Synthetic form of the endogenous peptide brain natriuretic peptide (BNP) approved for use in acute cardiac failure

Increases cGMP in smooth muscle cells and reduces venous and arteriolar tone

Nesiritide

Natrecor®

Natriuretic Peptide

Endothelin Receptor Antagonist

Bosentan (Tracleer®)

Produces vasodilation and cardiac inhibition

Bosentan

Tracleer®

Endothelin Receptor Antagonist